化学糖生物学 - Carolyn Bertozzi P1
本视频由科普中国和生物医学大讲堂出品
Carolyn Bertozzi (UC Berkeley) Part 1: Chemical Glycobiology
Part 1 A large part of an organism's complexity is not encoded by its genome but results from post-translational modification. Glycosylation, or the addition of sugar molecules to a protein is an example of such a modification. These sugars, or glycans, are often complex, branched molecules specific to particular cells. Cell surface glycans determine human blood types, allow viral infections and play a key role in tissue inflammation. See more at http://www.ibioseminars.org
生物糖组成像方法 - Carolyn Bertozzi P2
本视频由科普中国和生物医学大讲堂出品
Carolyn Bertozzi (UC Berkeley) Part 2: Imaging the Glycome
Since glycans cannot be labeled with genetically-encoded reporters such as GFP, bioorthoganal reactions have been developed to allow their labeling and imaging. In this lecture, Bertozzi describes the chemistry and imaging methodology used to view glycoproteins in cells and whole organisms. See more at http://www.ibioseminars.org
头足纲动物的伪装和信号 - Roger Hanlon P1
本视频由科普中国和生物医学大讲堂出品
Roger Hanlon (MBL) Part 1: Camouflage and Signaling in Cephalopods
Hanlon introduces the amazing adaptive coloration of cephalopods. He uses video and still photography to showcase their ability to rapidly change color, pattern and skin texture with fine control and a diversity of appearances, to produce camouflage or to send signals. He argues that all camouflage patterns in nature can be grouped into three types. In part 2, Hanlon shows us results from his lab that make a convincing case that the rapid adaptive coloration of cephalopods is controlled by their visual system; quite impressive for a color-blind animal! Part 3 focuses on the unique skin of cephalopods including the system of pigments and reflectors that allows it to quickly change to any hue and contrast, and the papillae musculature that allows the skin to deform and create multiple 3D textures.
对头足纲动物视觉感知机制的探索 - Roger Hanlon P2
本视频由科普中国和生物医学大讲堂出品
Roger Hanlon (MBL) Part 2: Exploring Mechanisms of Visual Perception
Hanlon introduces the amazing adaptive coloration of cephalopods. He uses video and still photography to showcase their ability to rapidly change color, pattern and skin texture with fine control and a diversity of appearances, to produce camouflage or to send signals. He argues that all camouflage patterns in nature can be grouped into three types. In part 2, Hanlon shows us results from his lab that make a convincing case that the rapid adaptive coloration of cephalopods is controlled by their visual system; quite impressive for a color-blind animal! Part 3 focuses on the unique skin of cephalopods including the system of pigments and reflectors that allows it to quickly change to any hue and contrast, and the papillae musculature that allows the skin to deform and create multiple 3D textures.
头足纲动物的可变化的皮肤细胞 - Roger Hanlon P3
本视频由科普中国和生物医学大讲堂出品
Roger Hanlon (MBL) Part 3: Changeable Skin
Hanlon introduces the amazing adaptive coloration of cephalopods. He uses video and still photography to showcase their ability to rapidly change color, pattern and skin texture with fine control and a diversity of appearances, to produce camouflage or to send signals. He argues that all camouflage patterns in nature can be grouped into three types. In part 2, Hanlon shows us results from his lab that make a convincing case that the rapid adaptive coloration of cephalopods is controlled by their visual system; quite impressive for a color-blind animal! Part 3 focuses on the unique skin of cephalopods including the system of pigments and reflectors that allows it to quickly change to any hue and contrast, and the papillae musculature that allows the skin to deform and create multiple 3D textures.
多细胞生物的新研究 - Richard Losick P2
本视频由科普中国和生物医学大讲堂出品
Richard Losick (Harvard) Part 2: New Research on Multicellularity
Part II presents research on the capacity of B. subtilis cells to form architecturally complex communities.
模式生物黑腹果蝇的综述
黑腹果蝇，又称果蝇, 是生物学研究中广泛应用的一种功能强大的模式生物，它在上个世纪对科学领域作出了极大的贡献。本短片首先对果蝇这个生物体做了一个介绍，包括其生理特征， 生命周期，生活环境和食物。然后解释了为什么果蝇是一个极好的模式生物。例如，果蝇在实验室的培养成本低廉， 其遗传学简单，生命周期短，可以快速进行大量样本数目的实验。接下来，我们将概括在果蝇研究领域的重大发现和杰出科学家，如托马斯·亨特·摩尔根。最后是 果蝇研究应用的例子，从遗传学到心血管和神经发育及疾病。本短片将给您全面概述黑腹果蝇这个及其重要且有影响力的模式生物。
模式生物概述: 秀丽隐杆线虫
秀丽隐杆线虫是一种生活在土壤中的微小蠕虫，从19世纪70年代初开始， 它就作为功能强大的模式生物被广泛应用。它最初被用作模式生物是由于以下的原因：不变的身体结构，遗传操作简单以及培养成本低廉。从那以后,秀丽线虫的应 用开始迅速发展, 并被用于众多的研究方向, 包括对运动中作用力的研究和对神经回路的探悉。
本短片概述了线虫的基础生物学, 很多发生在它短暂但传奇的研究历史中的里程碑事件的时间表，和以线虫作为模式生物的一些激动人心的应用。
啮齿动物的立体定位手术
立体定向（或立体）手术是一种用来操作活体动物大脑的方法。该技术使得研究人员能够通过使用立体定位图谱准确地定位大脑内的深层结构。立体定位图谱提供了每个脑区相对于颅骨上的解剖学标志的三维坐标。将颅骨暴露后，麻醉的动物被固定在被称为立体定位仪的专门仪器上，该仪器能使实验工具精确放置在定好的坐标上。立体定位手术是一项用途广泛的技术，可用来产生损伤，操纵基因表达，或将实验试剂施加到大脑里。
本视频文章概述了立体定位手术的原理，包括使用立体定位图谱和立体定位仪的说明，并介绍了读取测量探头移动的游标刻度的方法。随后的讨论概括了手术过程所需的步骤。最后，展示了该技术的广泛应用，如插入电极探针以测量大脑活动以及脑组织的遗传操作方法。