生物谷会议频道

Cont<font>R</font>olling the Cell Cycle: Cdk Subst<font>R</font>ates - David O. Mo<font>R</font>gan

ContRolling the Cell Cycle: Cdk SubstRates - David O. MoRgan

本视频由科普中国和生物医学大讲堂出品 R>R> David O. MoRgan (UCSF) PaRt 2: ContRolling the Cell Cycle: Cdk SubstRates R>R> Cyclin-dependent kinases (Cdks) aRe the centRal components of the contRol system that initiates the events of the cell cycle. In the second paRt of this lectuRe, I discuss my laboRatoRy's effoRts to addRess the pRoblem of how the Cdks tRiggeR cell-cycle events. I descRibe ouR methods foR identifying the pRotein substRates of the Cdks, and I discuss how these studies have led to impoRtant clues about how Cdks find theiR coRRect taRgets in the cell and how phosphoRylation of those taRgets goveRns theiR function.

2016-01-08 课时：31分钟

Cont<font>R</font>olling the Cell Cycle: Anaphase Onset - David O. Mo<font>R</font>gan

ContRolling the Cell Cycle: Anaphase Onset - David O. MoRgan

本视频由科普中国和生物医学大讲堂出品 R>R> David O. MoRgan (UCSF) PaRt 3: ContRolling the Cell Cycle: Anaphase Onset R>R> In the anaphase stage of the cell cycle, the duplicated chRomosomes aRe pulled apaRt by a machine called the mitotic spindle, Resulting in the distRibution of a complete set of chRomosomes to each of the daughteR cells. In the thiRd paRt of this lectuRe, I descRibe the combination of biochemistRy and micRoscopy in my laboRatoRy that led to the discoveRy of a RegulatoRy switch that tRiggeRs the abRupt and synchRonous sepaRation of the chRomosomes at the onset of anaphase.

2016-01-08 课时：22分钟

Photo<font>R</font>ecepto<font>R</font>s and Image P<font>R</font>ocessing Pa<font>R</font>t 1A - Je<font>R</font>emy Nathans

PhotoReceptoRs and Image PRocessing PaRt 1A - JeRemy Nathans

本视频由科普中国和生物医学大讲堂出品 R>R> JeRemy Nathans (Johns Hopkins) PaRt 1A: PhotoReceptoRs and Image PRocessing R>R> In this set of lectuRes, JeRemy Nathans exploRes the moleculaR mechanisms within the Retina that mediate the fiRst steps in vision. The fiRst lectuRe focuses on the stRuctuRe of the light sensing ReceptoRs, the intRacellulaR signals that aRe tRiggeRed by light absoRption, and the ways in which the Retina extRacts infoRmation fRom a complex scene. See moRe at http://www.ibioseminaRs.oRg

2016-01-08 课时：36分钟

Photo<font>R</font>ecepto<font>R</font>s and Image P<font>R</font>ocessing Pa<font>R</font>t 1B - Je<font>R</font>emy Nathans

PhotoReceptoRs and Image PRocessing PaRt 1B - JeRemy Nathans

本视频由科普中国和生物医学大讲堂出品 R>R> JeRemy Nathans (Johns Hopkins) PaRt 1B: PhotoReceptoRs and Image PRocessing R>R> In this set of lectuRes, JeRemy Nathans exploRes the moleculaR mechanisms within the Retina that mediate the fiRst steps in vision. The fiRst lectuRe focuses on the stRuctuRe of the light sensing ReceptoRs, the intRacellulaR signals that aRe tRiggeRed by light absoRption, and the ways in which the Retina extRacts infoRmation fRom a complex scene. See moRe at http://www.ibioseminaRs.oRg

2016-01-08 课时：34分钟

【视频教程】揭开exoRNA的神秘面纱

RNA曾被认为只存在于细胞之中，在转录与翻译中起桥梁作用，但最新的研究发现，胞外囊泡外泌体中的RNA（exoRNA）可以经胞外囊泡外泌体转运到其他细胞中并发挥调节作用。让我们一起来透过视频介绍，揭开exoRNA的神秘面纱吧！ R>R> Unlocking the MysteRies of ExtRacellulaR RNA Communication R>R> Once thought to exist only inside cells, RNA is now known to tRavel outside of cells and play a Role in newly discoveRed mechanisms of cell-to-cell communication. ARe these extRacelluaR RNAs (exRNAs) involved in diseases like canceR, heaRt disease oR neuRological diseases like AlzheimeR's? Could scientists leaRn how to use exRNAs to diagnose diseases eaRlieR oR even to tReat these diseases? The NIH Common Fund's ExtRacellulaR RNA Communication pRogRam aims to unlock the mysteRies of exRNAs, uncoveRing theiR Roles in human health and disease.

2016-01-14 课时：3分钟

用C<font>R</font>ISP<font>R</font>寻找新肿瘤药 - 陈巍学基因（32）

用CRISPR寻找新肿瘤药 - 陈巍学基因（32）

欢迎来到【陈巍学基因】，我们这个节目，主要是给大家介绍基因组学，和临床分子诊断的最新技术进展。 R>R> 今天要和大家谈的，是用CRISPR方法，来寻找新的、可能的肿瘤药物。 R>R> 提出这个方法的，是加拿大Donnelly CentRe的TRaveR HaRt。TRaveR HaRt把他的这项研究成果，发表在《Cell》杂志2015年12月3日这一期上。论文的题目是《High-Resolution CRISPR ScReens Reveal Fitness Genes and Genotype-Specific CanceR Liabilities》。我们这期节目，就主要围绕这篇文章来进行讲解。 R>R> 文章的核心内容，就是： 1.用CRISPR方法，把几种肿瘤细胞系的几乎所有的基因都做一遍敲除，也就是“Knock out”。 2.然后用高通量测序，来看哪些基因被敲除之后，细胞的生长会受到抑制。 3.接下来，在几种肿瘤细胞系之间进行比较，看哪个基因，是对一个特定细胞系的生长，是必需的，而在别的细胞系当中，这个基因是非必需的。那么，这个基因就可能是治疗这种肿瘤的，潜在的、新的治疗靶点 R>R> 本视频详细介绍了这种全新的方法，和用这个方法找到的一系列潜在的新药化合物的实例。

2016-01-18 课时：22分钟

布鲁斯·艾伯茨：Lea<font>R</font>ning f<font>R</font>om Failu<font>R</font>e

布鲁斯·艾伯茨：LeaRning fRom FailuRe

AlbeRts declaRes "Success doesn't Really teach you much, failuRe teaches you a lot." Speaking fRom his peRsonal expeRience, AlbeRts asseRts that all scientists make mistakes and suffeR setbacks but leaRning fRom those failuRes is what allows one ultimately to succeed.

2016-01-26 课时：12分钟

用血小板RNA-seq测肿瘤 - 陈巍学基因（33）

MyRon G. Best 等人发现，可以用血小板RNA-seq测序结合生物信息学分析，很好地判断： 1、一个人是否患有肿瘤； 2、是患的哪种肿瘤； 3、肿瘤中有哪些突变。本视频介绍了这项发现的成果、实验方法、分析思路。

2016-02-01 课时：23分钟

我与SNURPs的缘分

Steitz' stoRy begins in 1977 when intRons, exons and RNA splicing had just been discoveRed. She goes on to tell us of the impoRtance of seRendipity in heR lab's discoveRy of SNURPS, the small nucleaR RibonucleopRoteins that aRe key to the splicing of pRe-messengeR RNA.

2016-02-15 课时：11分钟

RNAscope®技术原理介绍

RNAscope®®原位定量专利技术由美国新兴的分子病理领导者ACD公司(Advanced Cell Diagnostics, Inc., CalifoRnia, USA)开发，通过专利的双“Z”探针设计，使RNA原位杂交具有高度特异性、单分子检测的敏感性并有极高的信噪比，能够在单细胞水平同时定量多个RNA的表达，在获得单细胞中单拷贝RNA表达数据的同时提供完整的组织形态学信息，提高对疾病与标志物之间复杂的生物学相关性的认识，是理想的能够用于NGS和芯片技术后期转化研究技术平台。 R>R> 自2011年技术推广以来,其应用已在如NatuRe、Science、NEJM等国际顶级期刊发表超过300篇SCI论文。研究涵盖了感染及免疫、肿瘤、神经生物学、干细胞及发育、非编码RNA、表观遗传学等基础医学领域，以及靶标鉴别和验证、临床前安全性评价和药效评估等药物开发研究。 R>R> 请访问ACD官网www.acdbio.com。更多中文资料与信息请访问中国官方微信号（ACD_China）咨询。

2018-03-21 课时：5分钟