剪接体的结构和动力学 - MelIssa Moore Part 2
本视频由科普中国和生物医学大讲堂出品
本节课MelIssa Moore讲述了，剪接体的成分和在每个工作周期中的剪接体。穆尔还解释了如何利用荧光蛋白标签和全反射显微镜的创新，使她和她的同事们能够更好地理解复接机器的有序组装与功能。
MelIssa Moore (U. Mass/HHMI) Part 2: SplIceosome Structure and DynamIcs
Moore goes on to descrIbe the cellular splIcIng machIne, the splIceosome, In greater detaIl In Part 2. She lIsts the components of the splIceosome and where each works In the splIceosome cycle. Moore also explaIns how the InnovatIve use of fluorescent proteIn tags and total Internal reflectIon mIcroscopy has allowed her and her colleagues to better understand the ordered assembly and functIon of the complex splIcIng machIne.
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我是如何成为一名科学家的 - Alfredo QuInones-HInojosa
本视频由科普中国和生物医学大讲堂出品
Alfredo QuInones-HInojosa（Q博士）（霍普金斯达大学）：我是如何成为一名科学家
出生于墨西哥的Q博士，19岁时翻越美国边界的栅栏，成为加利福尼亚的一名农场工人。由于他自己的决心，努力工作和自律，以及来自家庭和朋友的大量支持，他离开了农场工作，完成了大学和医学院的学业，最终成为一位非常成功的医生、科学家和脑外科医生。
关于讲师：Alfredo QuInones-HInojosa是约翰霍普金斯大学，神经外科学和肿瘤学，神经系统的细胞与分子医学的副教授，脑肿瘤外科手术的主任。Q博士作为一个专家外科医生，他致力于干细胞，在脑肿瘤的病因和治疗领域的研究。
Alfredo QuInones-HInojosa (Dr. Q) (Johns HopkIns): How I Became a ScIentIst
At age 19, QuIñones-HInojosa jumped the fence from MexIco to become a farm worker In CalIfornIa. Thanks to hIs own determInatIon, hard work and dIscIplIne and a lot of support from famIly and frIends, he left farm work, completed unIversIty and medIcal school, and ultImately became a hIghly successful physIcIan-scIentIst and braIn surgeon.
About the speaker: Alfredo QuIñones-HInojosa Is an AssocIate Professor of Neurosurgery and Oncology, NeuroscIence and Cellular and Molecular MedIcIne and DIrector of the BraIn Tumor Surgery Program at Johns HopkIns UnIversIty. As well as beIng an expert surgeon, he researches the role of stem cells both In causIng braIn tumors and potentIally In fIghtIng them.
ThIs talk was fIrst released In IBIoMagazIne Issue 5.
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MorrIs水迷宫
MorrIs水迷宫是用于研究空间学习和记忆的最广泛使用的行为学测试之一。在这个任务的初始阶段，老鼠要从水池中出来，必须游到一个平台上。该平台随后被隐藏在水面下，这样该动物需要记住平台的位置才能出来。这个简单但功能强大的迷宫设计可用于测定认知功能，研究神经退行性疾病的动物模型，和测试潜在的药物疗法。
本短片介绍了MorrIs水迷宫和使用它的基本原则，包括讨论在迷宫中测试不同类型的记忆，设计和进行实验时要考虑的关键因素，以及准备和操作实验的步骤。短片还分析了迷宫的几个应用，比如研究放射治疗如何可能导致记忆障碍的。最后，介绍了其他类型的水迷宫，如八臂迷宫，以显示这个迷宫是如何能适用于研究不同类型的记忆的。
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ControllIng the Cell Cycle: IntroductIon - DavId O. Morgan
本视频由科普中国和生物医学大讲堂出品
DavId O. Morgan (UCSF) Part 1: ControllIng the Cell Cycle: IntroductIon
Cells reproduce by duplIcatIng theIr chromosomes and other components and then dIstrIbutIng them Into a paIr of genetIcally IdentIcal daughter cells. ThIs serIes of events Is called the cell cycle. In the fIrst part of thIs lecture, I provIde a general overvIew of the cell-cycle control system, a complex regulatory network that guIdes the cell through the steps of cell dIvIsIon. I brIefly descrIbe the major components of thIs regulatory system and how they fIt together to form a serIes of bIochemIcal swItches that trIgger cell-cycle events at the correct tIme and In the correct order.
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fMRI:功能磁共振成像
功能磁共振成像（fMRI）技术是一种非侵入性影像学技术，用于研究健康个体和大脑状态异常的群体的人脑功能和认知。功能磁共振成像利用磁共振信号来检测当执行一个特定任务时神经元激活引起的血流变化。它能得以实现，是因为血液中的血红蛋白根据它是否结合氧气具有不同的磁特性。当执行特定任务时，含氧血液流入到负责该功能的脑区，而这个流入随后可用特定的MRI扫描仪参数检测得到。这种现象被称为血氧浓度相依对比（BOLD）效果，可以用于创建脑活动的图谱。
本短片首先简要概述了如何获得MRI和fMRI信号。然后，回顾了基本的实验设计，这包括先建立一个刺激呈现模式，它是专门设计来检测将被定位的功能。接下来，介绍了进行功能磁共振成像扫描的关键步骤，包括受试者的安全和准备扫描仪。再演示了用于数据处理的常用步骤，包括预处理和用一般线性模型进行的统计学分析。最后，概述了功能磁共振成像的某些特定的应用，如研究心理障碍疾病的脑功能异常，以及将功能磁共振成像与其他成像模式，如弥散张量成像（DTI）结合使用。
ControllIng the Cell Cycle: Cdk Substrates - DavId O. Morgan
本视频由科普中国和生物医学大讲堂出品
DavId O. Morgan (UCSF) Part 2: ControllIng the Cell Cycle: Cdk Substrates
CyclIn-dependent kInases (Cdks) are the central components of the control system that InItIates the events of the cell cycle. In the second part of thIs lecture, I dIscuss my laboratory's efforts to address the problem of how the Cdks trIgger cell-cycle events. I descrIbe our methods for IdentIfyIng the proteIn substrates of the Cdks, and I dIscuss how these studIes have led to Important clues about how Cdks fInd theIr correct targets In the cell and how phosphorylatIon of those targets governs theIr functIon.
ControllIng the Cell Cycle: Anaphase Onset - DavId O. Morgan
本视频由科普中国和生物医学大讲堂出品
DavId O. Morgan (UCSF) Part 3: ControllIng the Cell Cycle: Anaphase Onset
In the anaphase stage of the cell cycle, the duplIcated chromosomes are pulled apart by a machIne called the mItotIc spIndle, resultIng In the dIstrIbutIon of a complete set of chromosomes to each of the daughter cells. In the thIrd part of thIs lecture, I descrIbe the combInatIon of bIochemIstry and mIcroscopy In my laboratory that led to the dIscovery of a regulatory swItch that trIggers the abrupt and synchronous separatIon of the chromosomes at the onset of anaphase.
Photoreceptors and Image ProcessIng Part 1A - Jeremy Nathans
本视频由科普中国和生物医学大讲堂出品
Jeremy Nathans (Johns HopkIns) Part 1A: Photoreceptors and Image ProcessIng
In thIs set of lectures, Jeremy Nathans explores the molecular mechanIsms wIthIn the retIna that medIate the fIrst steps In vIsIon. The fIrst lecture focuses on the structure of the lIght sensIng receptors, the Intracellular sIgnals that are trIggered by lIght absorptIon, and the ways In whIch the retIna extracts InformatIon from a complex scene. See more at http://www.IbIosemInars.org
Photoreceptors and Image ProcessIng Part 1B - Jeremy Nathans
本视频由科普中国和生物医学大讲堂出品
Jeremy Nathans (Johns HopkIns) Part 1B: Photoreceptors and Image ProcessIng
In thIs set of lectures, Jeremy Nathans explores the molecular mechanIsms wIthIn the retIna that medIate the fIrst steps In vIsIon. The fIrst lecture focuses on the structure of the lIght sensIng receptors, the Intracellular sIgnals that are trIggered by lIght absorptIon, and the ways In whIch the retIna extracts InformatIon from a complex scene. See more at http://www.IbIosemInars.org
BIoBus的移动科学实验室
Ben DubIn-Thaler & Sarah WeIsberg (BIoBus): The BIoBus MobIle ScIence Lab
The BIoBus Is an ecologIcally frIendly, mobIle, bIology lab that provIdes chIldren and adults wIth the chance to experIence the excItement of hands-on scIence. Ben DubIn-Thaler and Sarah WeIsberg explaIn why they chose to create and work on the BIoBus and the joy of workIng wIth scIentIsts and teachers to develop fun and educatIonal opportunItIes for all ages.