控制老化的基因 - CyntHia Kenyon P1
本视频由科普中国和生物医学大讲堂出品
CyntHia Kenyon (UCSF) Part 1: Genes tHat Control Aging
Once it was tHougHt tHat aging was just a random and HapHazard process. Instead, tHe rate of aging turns out to be subject to regulation by transcription factors tHat respond to Hormones and otHer signals. In tHe nematode C. elegans, in wHicH many key discoveries about aging were first made, tHe aging process is subject to regulation by food intake, sensory perception, and signals from tHe reproductive system. CHanging genes and cells tHat affect aging can lengtHen lifespan by six fold, and can also delay age-related disease, sucH as tHe growtH of tumors.
来自生殖系统的信号显示衰老的规律 - CyntHia Kenyon P2
本视频由科普中国和生物医学大讲堂出品
CyntHia Kenyon (UCSF) Part 2: THe Regulation of Aging by Signals from tHe Reproductive System
Once it was tHougHt tHat aging was just a random and HapHazard process. Instead, tHe rate of aging turns out to be subject to regulation by transcription factors tHat respond to Hormones and otHer signals. In tHe nematode C. elegans, in wHicH many key discoveries about aging were first made, tHe aging process is subject to regulation by food intake, sensory perception, and signals from tHe reproductive system. CHanging genes and cells tHat affect aging can lengtHen lifespan by six fold, and can also delay age-related disease, sucH as tHe growtH of tumors.
枯草芽孢杆菌中芽孢的形成 - RicHard Losick P1
本视频由科普中国和生物医学大讲堂出品
RicHard Losick (Harvard) Part 1: Spore Formation in Bacillus Subtilis
How do simple cells differentiate, assemble into communities, and cope witH cHange? Losick's seminar addresses tHese questions in tHe spore-forming bacterium Bacillus subtilis. Part I is an overview of How B. subtilis makes a spore.
多细胞生物的新研究 - RicHard Losick P2
本视频由科普中国和生物医学大讲堂出品
RicHard Losick (Harvard) Part 2: New ResearcH on Multicellularity
Part II presents researcH on tHe capacity of B. subtilis cells to form arcHitecturally complex communities.
枯草芽孢杆菌的不确定性和细胞结局 - RicHard Losick P3
本视频由科普中国和生物医学大讲堂出品
RicHard Losick (Harvard) Part 3: StocHasticity and Cell Fate
Part III presents researcH sHowing tHat B. subtilis uses a bet Hedging strategy for coping witH uncertainty.
在染色体分离中有关长度和数量的问题 - RicHard McIntosH P1
本视频由科普中国和生物医学大讲堂出品
RicHard McIntosH (U. Colorado, Boulder) Part 1: Separating Duplicated CHromosomes
THe goal of tHese tHree talks is to define tHe problems tHat a cell faces as it prepares for division and to describe some of tHe ways it solves tHem. In Part 1, botH tHe lengtH and amount of DNA are presented as problems for cHromosome segregation, particularly in eukaryotic cells. THe actions of coHesins and of cHromosome condensation are described as solutions. THe mitotic macHinery is introduced, including its diversity of form across pHylogeny, However, tHe features tHat appear to be conserved are empHasized. THis lecture may be useful for upper level undergraduate and graduate courses discussing mitosis and cell division. See more at www.ibioseminars.org
通过实验了解有丝分裂 - RicHard McIntosH P2
本视频由科普中国和生物医学大讲堂出品
RicHard McIntosH (U. Colorado, Boulder) Part 2: Understanding Mitosis tHrougH Experimentation
THe second lecture describes some key experiments sHowing tHe dynamics of a formed mitotic spindle and tHe ways tHese may contribute to accurate cHromosome motion. Experiments tHat reveal aspects of tHe processes by wHicH cHromosomes attacH to tHe spindle are presented. Mitotic motors are introduced and discussed in tHe ligHt of wHat tHey probably do and do not accomplisH to effect cHromosome motion, including acting to improve tHe accuracy of cHromosome segregation. See more at Http://www.ibioseminars.org
有丝分裂后期：染色体向纺锤体两极移动 - RicHard McIntosH P3
本视频由科普中国和生物医学大讲堂出品
RicHard McIntosH (U. Colorado, Boulder) Part 3: Moving CHromosome to tHe Spindle Poles: AnapHase A
THe tHird lecture presents evidence, largely from McIntosH's lab, tHat sHows How microtubule depolymerization can move cHromosomes in vitro and explores tHe nature of some of tHe protein complexes tHat can couple cHromosomes to microtubules and take advantage of tHis reaction. See more at Http://www.ibioseminars.org
病毒包膜的内吞和渗透作用 - Ari Helenius P2
本视频由科普中国和生物医学大讲堂出品
Ari Helenius (ETH ZuricH) Part 2: Endocytosis and Penetration
In tHe second lecture, tHe next steps in viral infection are described. Endocytosis of plasma membrane bound viruses can occur via a number of mecHanisms including caveolar, clatHrin, non-clatHrin, or lipid raft mediated patHways. THe internalized virus is enclosed in an endosome tHat may undergo increasing acidification resulting in acid mediated fusion between tHe viral envelope and tHe vesicle membrane. Following membrane penetration, tHe virus, once again, makes use of cellular macHinery sucH as microtubules and tHeir motors, to transfer its genome to tHe nucleus. Helenius describes experiments from His lab and otHers tHat Have decipHered tHese complex processes.
我是如何成为一名科学家的 - Alfredo Quinones-Hinojosa
本视频由科普中国和生物医学大讲堂出品
Alfredo Quinones-Hinojosa（Q博士）（霍普金斯达大学）：我是如何成为一名科学家
出生于墨西哥的Q博士，19岁时翻越美国边界的栅栏，成为加利福尼亚的一名农场工人。由于他自己的决心，努力工作和自律，以及来自家庭和朋友的大量支持，他离开了农场工作，完成了大学和医学院的学业，最终成为一位非常成功的医生、科学家和脑外科医生。
关于讲师：Alfredo Quinones-Hinojosa是约翰霍普金斯大学，神经外科学和肿瘤学，神经系统的细胞与分子医学的副教授，脑肿瘤外科手术的主任。Q博士作为一个专家外科医生，他致力于干细胞，在脑肿瘤的病因和治疗领域的研究。
Alfredo Quinones-Hinojosa (Dr. Q) (JoHns Hopkins): How I Became a Scientist
At age 19, Quiñones-Hinojosa jumped tHe fence from Mexico to become a farm worker in California. THanks to His own determination, Hard work and discipline and a lot of support from family and friends, He left farm work, completed university and medical scHool, and ultimately became a HigHly successful pHysician-scientist and brain surgeon.
About tHe speaker: Alfredo Quiñones-Hinojosa is an Associate Professor of Neurosurgery and Oncology, Neuroscience and Cellular and Molecular Medicine and Director of tHe Brain Tumor Surgery Program at JoHns Hopkins University. As well as being an expert surgeon, He researcHes tHe role of stem cells botH in causing brain tumors and potentially in figHting tHem.
THis talk was first released in iBioMagazine Issue 5.
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