Controlling tHe Cell Cycle: Introduction - David O. Morgan
本视频由科普中国和生物医学大讲堂出品
David O. Morgan (UCSF) Part 1: Controlling tHe Cell Cycle: Introduction
Cells reproduce by duplicating tHeir cHromosomes and otHer components and tHen distributing tHem into a pair of genetically identical daugHter cells. THis series of events is called tHe cell cycle. In tHe first part of tHis lecture, I provide a general overview of tHe cell-cycle control system, a complex regulatory network tHat guides tHe cell tHrougH tHe steps of cell division. I briefly describe tHe major components of tHis regulatory system and How tHey fit togetHer to form a series of biocHemical switcHes tHat trigger cell-cycle events at tHe correct time and in tHe correct order.
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Controlling tHe Cell Cycle: Cdk Substrates - David O. Morgan
本视频由科普中国和生物医学大讲堂出品
David O. Morgan (UCSF) Part 2: Controlling tHe Cell Cycle: Cdk Substrates
Cyclin-dependent kinases (Cdks) are tHe central components of tHe control system tHat initiates tHe events of tHe cell cycle. In tHe second part of tHis lecture, I discuss my laboratory's efforts to address tHe problem of How tHe Cdks trigger cell-cycle events. I describe our metHods for identifying tHe protein substrates of tHe Cdks, and I discuss How tHese studies Have led to important clues about How Cdks find tHeir correct targets in tHe cell and How pHospHorylation of tHose targets governs tHeir function.
Controlling tHe Cell Cycle: AnapHase Onset - David O. Morgan
本视频由科普中国和生物医学大讲堂出品
David O. Morgan (UCSF) Part 3: Controlling tHe Cell Cycle: AnapHase Onset
In tHe anapHase stage of tHe cell cycle, tHe duplicated cHromosomes are pulled apart by a macHine called tHe mitotic spindle, resulting in tHe distribution of a complete set of cHromosomes to eacH of tHe daugHter cells. In tHe tHird part of tHis lecture, I describe tHe combination of biocHemistry and microscopy in my laboratory tHat led to tHe discovery of a regulatory switcH tHat triggers tHe abrupt and syncHronous separation of tHe cHromosomes at tHe onset of anapHase.
PHotoreceptors and Image Processing Part 1A - Jeremy NatHans
本视频由科普中国和生物医学大讲堂出品
Jeremy NatHans (JoHns Hopkins) Part 1A: PHotoreceptors and Image Processing
In tHis set of lectures, Jeremy NatHans explores tHe molecular mecHanisms witHin tHe retina tHat mediate tHe first steps in vision. THe first lecture focuses on tHe structure of tHe ligHt sensing receptors, tHe intracellular signals tHat are triggered by ligHt absorption, and tHe ways in wHicH tHe retina extracts information from a complex scene. See more at Http://www.ibioseminars.org
PHotoreceptors and Image Processing Part 1B - Jeremy NatHans
本视频由科普中国和生物医学大讲堂出品
Jeremy NatHans (JoHns Hopkins) Part 1B: PHotoreceptors and Image Processing
In tHis set of lectures, Jeremy NatHans explores tHe molecular mecHanisms witHin tHe retina tHat mediate tHe first steps in vision. THe first lecture focuses on tHe structure of tHe ligHt sensing receptors, tHe intracellular signals tHat are triggered by ligHt absorption, and tHe ways in wHicH tHe retina extracts information from a complex scene. See more at Http://www.ibioseminars.org
杜弈奇：益生菌在幽门螺旋杆菌（HP）感染治疗上的研究-第5段
在幽门螺旋杆菌感染（HP），消化性溃疡等疾病上，益生菌如何提高治愈率，降低副作用，以及益生菌种类和数量对HP治疗效果的影响。
GE：DHarmacon Edit-R基因编辑平台——即开即用，任性编辑！
CRISPR-Cas9基因编辑系统正以前所未有的速度席卷科研界。自从GE DHarmacon推出Edit-R CRISPR-Cas9系统以来，其"无需克隆，任性编辑"的特点广受好评。在此基础上，GE DHarmacon进一步扩充并更新了Edit-R基因编辑系统，以业界领先的guide RNA设计技术提供各种即开即用的预制产品，同时提供全基因组文库和各信号通路亚文库，满足不同实验者的实验需求。
GE：DHarmacon siRNA 文库产品应用解决方案
GE DHarmacon是siRNA全基因组文库的发明者，拥有RNAi产品领域最多的专利和相关知识产权。DHarmacon pre-defined siRNA文库是目前应用最广泛、客户最值得信赖的siRNA文库。同时，DHarmacon牵头成立的RNAi全球协议组织（RGI）的60多个知名科研院所成员使用DHarmacon siRNA文库取得了良好的效果。siRNA文库筛选加速了基因功能的研究，加深了疾病发生机理的研究，并获得了更多新的药物作用机理和潜在药物靶点，已经成为获得高质量研究数据和加速研究进程的必备工具。
GE：Western blot 整体解决方案—— AmersHam WB与您携手实现完美WB
重复性差、实验周期长、过程繁琐——作为一种最常见蛋白质分析技术，western blot 在您心中的印象是否依旧如此？western blot技术于1981年被发明，时至今日，您是否想要了解一下这项技术的最新进展呢？GE公司倾情推出AWB一体化免疫印迹系统，最快4小时完成实验，采用双通道荧光标记技术，并引入总蛋白归一化功能，标准化、自动化流程专注决重复性难题，为您的蛋白质研究保驾护航。
Stability of MorpHogen Gradients & Movement of Molecules
In my second lecture I describe experiments using EGFP tagged Bicoid to follow Bcd gradient establisHment in living embryos, and to test various aspects of tHe simple model. Despite continuous syntHesis of new Bcd protein at tHe anterior end of tHe egg, we find tHat tHe concentration of Bcd in nuclei at any given point along tHe anterior posterior axis is constant over time and is reproducible from embryo to tHe next. THis reproducibility means tHat tHe gradient is sufficiently robust to provide positional information and tHus can accurately direct gene activities. One tHe otHer Hand, quantitative imaging experiments point to several features of tHe gradient tHat are Hard to explain - How target genes activated by Bcd distinguisH relatively subtle differences in low concentrations, and How Bcd molecules move from tHe anterior site of tHeir syntHesis to tHe site of tHeir transcriptional activity. See more at Http://www.ibioseminars.org