让细胞生物学变得更有生机活力
Janet Iwasa recalls the animation that first led her to realize how much more information can be included in an animation compared to a static image. She explains that animations can provide a visualization of a hypothesis and bring together structural data, protein-protein interactions and dynamic information in a process that often helps researchers refine their models.
生物技术的职业生涯
Dr. Tessier-Lavigne is Executive Vice-President of Research and Chief Scientific Officer at Genentech where he is responsible for directing all basic and disease research and drug discovery efforts. He also maintains his own research group focused on the wiring of the developing brain, as well as neuronal re-wiring after injury and the process of neurodegeneration.
一个关于定量生物学的设想
Rob Phillips is Professor of Applied Physics and Bioengineering at The California Institute of Technology. His research focuses on understanding the physical basis of biological phenomena. Phillips is a co-author of the recently published textbook " Physical Biology of the Cell". Prior to the privilege of a life in science, he spent seven years of travel, self-study and work as an electrician.
高中辍学男孩，如何成为生物教授
When Ramirez was a child, his family moved from northern California to rural Mexico. He did not attend high school. After 4 years of working on the family ranch, Ramirez returned to the USA to resume his education. With perseverance and encouraging mentors, he obtained his GED, his Bachelor's degree, and ultimately a PhD degree. Ramirez demonstrates that you can become a successful scientist even if the path is neither easy nor direct.
About the speaker: Robert Ramirez recently became Associate Dean of Science and Engineering at San Francisco State University where he enjoys interacting with a diverse group of colleagues and students. He is also Professor of Cellular and Molecular Biology and his lab studies novel responses to osmotic stress in yeast.
对野生动物摄影的爱
As a child, Susan McConnell would spend hours watching wood rats carrying out their complex social lives in a woodpile. In this interview, she explains how her early interest in animal behavior formed the underpinnings of two passions in her life: understanding how neural circuits are assembled during development (which ultimately regulates animal behavior, and forms the main pursuit of her lab), and her love for wildlife photography, which she pursues around the globe.
顶复动物亚门—最原始、最简单、最低等的单细胞动物
David Roos (U Penn) Part 1: Biology of Apicomplexan Parasites
There are more than 5000 species of single-celled eukaryotes in the biological phylum known as the Apicomplexa, including the parasites responsible for malaria, neurological birth defects, and opportunistic infections associated with HIV/AIDS. These ancient protozoa provide a unique window into the evolution of subcellular organelles that have long fascinated cell biologists. Familiar features help to elucidate the origins, functions and design parameters for the secretory pathway, endosymbiotic organelles, the cytoskeleton, and cell cycle control. Conversely, parasite-specific organelles highlight the evolutionary diversity of eukaryotes, and suggest novel targets for treating disease. See more at http://www.ibioseminars.org
研究寄生虫的质体，提供药物开发的新靶点
David Roos (U Penn) Part 2: The apicomplexan plastid
Antibiotics are effective because they kill bacteria without harming humans and other eukaryotes (organisms with cells that contain nuclei). So why are the eukaryotic parasites responsible for malaria and toxoplasmosis killed by drugs like clindamycin? Multidisciplinary studies integrating molecular genetics, cell biology, biochemistry, pharmacology and computational genomics reveal that such drugs target an unusual organelle. The "apicoplast" was acquired when an ancestral organism 'ate' a eukaryotic alga, and retained the algal plastid -- a relative of plant chloroplasts derived from a bacterial ancestor. Although no longer photosynthetic, the apicoplast is essential for parasite survival, providing new targets for drug development. See more at http://www.ibioseminars.org
从古希腊到21世纪，对多细胞生物中的再生能力的研究
Alejandro Sanchez-Alvarado (Stowers Institute for Medical Research) Part 1: History of Regeneration
Regeneration has fascinated philosophers and scientists since the beginning of history. The wide but uneven distribution of regenerative capacities among multicellular organisms is puzzling, and the permissive/inhibitory mechanisms regulating this attribute in animals remain a mystery. In the first part of this lecture, I will provide a general history of regeneration research from ancient Greece to the beginning of the 20th century. Key concepts will be introduced in their appropriate historical context, and many of the unanswered questions put forward by the problem of regeneration will be discussed.
Alejandro Sánchez Alvarado moved from the University of Utah to the Stowers Institute for Medical Research in 2011.
GE：多功能激光成像技术在分子生物学领域的应用
您的分子生物学实验室是否面临各种各样的成像要求？PCR后核酸成像，蛋白电泳考染成像，SSCP银染成像遍布各大实验室；Souther、Northern、Western面面俱到；各种荧光标记探针，荧光ELISA检测，EMSA检测随后而来。您的研究还涉及到转基因植物，转基因昆虫？课题组新合成了小分子药物，它在动物体内将如何代谢？以上种种都可以通过多功能激光成像的技术帮您解决。
GE：抗体药物开发中细胞培养基的筛选、优化与补料策略
在抗体药物的开发过程中如何选择合适的无血清细胞培养基，在实验结果未达到预期要求时，如何做培养基的优化，及feed-batch培养模式下，如何优化补料策略，来提升细胞状态、延长表达周期、提高抗体产量。