细胞程序性死亡的发现
Horvitz recalls the "aha!" moment when he realized that his lab's work on programmed cell death, or apoptosis, in C. elegans was relevant to cancer in humans. This finding solidified his belief that the fundamental principles of biology are likely conserved across most species.
风险在科学发现的中心
Yamamoto argues that the trait that separates the best scientists from the rest is the willingness to take risks. He takes Francois Jacob as an example and encourages young scientists to try bold and uncertain approaches to problems since risk taking is at the heart of discovery.
冒险和发现的爱，由科学家和登山者共享
Louis Reichardt has experienced both success and tragedy in his efforts to climb the world's highest summits. Here he recalls his spectacular ascents of the two highest mountains in the world. In 1978, he reached the summit of K2 making him the first American ever to do so. Five years later, he joined a team that reached the peak of Mount Everest via the challenging east face, a feat that has never been repeated. Reichardt discusses the impact of mountaineering on his scientific career and the love of adventure and discovery that is shared by scientists and climbers.
未折叠蛋白反应的发现
Proteins that are secreted from the cell or inserted into the plasma membrane, transit through the endoplasmic reticulum where they are properly folded and assembled and may undergo post-translational modification. Walter tells the story of the exciting discovery made in his lab of the "unfolded protein response", a feedback pathway that ensures that the cell makes enough ER to properly modify all the secreted proteins in the cell.
肌球蛋白和驱动蛋白的探索发现之旅
Vale explains how doing science often follows a winding path with unexpected, sometimes wonderful surprises, and uses his own story to illustrate his point. When Vale was a graduate student, he initially hoped to show that myosin was involved in axonal transport, but ended up discovering a new molecule which he called kinesin.
深入地表以下，发现美景和科学
洞穴探险家、地理学家弗朗西斯科·绍罗深入位于我们脚底的隐藏大陆，调查地球深处那些从未被人踏足过的黑暗之地。在南美洲壮丽的特普伊山，他发现了新的矿物质和与世隔绝、独自进化的昆虫，他还运用自己关于这些“外星世界”的知识来训练宇航员。
发现细胞和生物的设计原则
“最根本的物理原理允许大型蜂窝结构的电磁辐射显现。” 从动物的内耳纤毛螺旋叶绿体的绿藻水绵细胞结构，有巨大的多样性。这些结构是精确定义的，通常是动态的。研究认为，蛋白质折叠的平衡理论无法解释细胞如何建立特定大小的大型组件，所以科学家们正在开发一种新的理论的细胞结构检测。
秦胜营：中国人群药物反应生物标志物的发现与验证
介绍了中国人群药物反应分子标记物的发现与确认，提到了基因相关的药物严重副作用。对比了美国与中国药物不良反应危害。提到了药物的种群差异和基因差异。提到了第八届国际皮肤药物不良反应大会。肿瘤药物基因组学研究以及个体化医学中的一系列里程碑性事件。临床复杂性疾病药物基因组学研究。介绍了基于药物代谢酶微粒体的新药安全性评价微流控芯片。
李松丽：精准医疗之蛋白生物标志物的发现，优化，验证和应用
介绍了精准医学的一些内容，提到了蛋白质生物标志物发现流程，提到了生物标志物高通量检测的必要性及应用；基于免疫反应的高通量检测技术；血清中肾脏标志物的筛选；引起免疫反应实验非重复性的原因。提到了Luminex技术在白血病抗药机理研究中的应用。