郭彤：eCliNIcal革新与趋势
A remarkable transformation is emerging of the way the biopharmaceutical industry conducts global cliNIcal trials. Coupled with this much needed evolution are new challenges specific to the increasing role that information technology will play to enable the new cliNIcal development landscape. Of the many challenges facing the biopharmaceutical industry today, the critical need for greater operational efficiency in cliNIcal drug development is paramount. In the past decades, we have seen many technology advancements, including cliNIcal trial management systems (CTMS), electroNIc trial master files (eTMFs), open standards, mobile access, tablets, and cloud computing. This presentation will discuss the above challenges and review the new trends of technology enabled solutions in cliNIcal research. .
Michael MerzeNIch:谈重塑大脑
神经学家Michael MerzeNIch谈论大脑的神秘而强大的功能之一：大脑主动重塑自身的能力。他正在研究利用大脑的可塑性来增强我们的技能以及恢复缺失的功能。
Joel SelaNIkio:令人惊讶的医疗保健大数据革新开端
收集关于全球健康的数据本是一个不完美的过程：工作人员徒步穿过村庄去挨家挨户敲门问问题，在纸质表格上写下答案，然后输入数据——然后从这满是漏洞的信息中，各个国家做出重大的决策。数据极客约尔·塞拉尼科谈论了在过去几十年来关于收集医疗健康数据的质的改变——从掌上电脑到Hotmail，现在又转移到云端。
Targets-based therapy for leukemia: opportuNIty and challenge
优点主要为：能增强患者的免疫力，防止肿瘤的转移和复发，对病人机体的损伤小。 在我国，现在普遍开展的树突状细胞（DC）和细胞因子诱导的杀伤细胞（CIK）的生物疗法被广泛应用。
金颖：Fox3 suppresses NFAT-mediated differentiation to maintain self-renewal of embryoNIc stem cells
金颖教授为分子发育生物学研究室主任，健康科学中心研究员。金教授介绍了Fox3通过抑制NFAT介导的分化维持了胚胎干细胞的自我更新的机制等前沿发现。
Pluripotency-associated transcription factor Foxd3 is required for maintaiNIng pluripotent cells. However, molecular mechaNIsms underlying its function are largely unknown.
Here, we report that Foxd3 suppresses differentiation induced by Calcineurin-NFAT signaling to maintain the ESC identity. MechaNIstically, Foxd3 interacts with NFAT proteins and recruits co-repressor Tle4, a member of the Tle suppressor family highly expressed in undifferentiated ESCs, to repress NFATc3’s transcriptional activities.
Furthermore, global transcriptome analysis shows that Foxd3 and NFATc3 co-regulate a set of differentiation-associated genes in ESCs. Collectively, our study establishes a molecular and functional link between a pluripotency-associated factor and an important ESC differentiation-inducing pathway.
Western Blot Using The invitrogen NuPAGE Novex Bis-Tris MiNIGel System(Aubin Penna.Ph.D)
Western Blot Using The invitrogen NuPAGE Novex Bis-Tris MiNIGel System(Aubin Penna.Ph.D)
细菌交流通过群感效应 - BonNIe Bassler P1
本视频由科普中国和生物医学大讲堂出品
BonNIe Bassler (Princeton) Part 1: Bacterial CommuNIcation via Quorum Sensing
Bacteria, primitive single-celled orgaNIsms, commuNIcate with chemical languages that allow them to synchroNIze their behavior and thereby act as enormous multi-cellular orgaNIsms. This process is called quorum sensing and it enables bacteria to successfully infect and cause disease in plants, aNImals, and humans. Investigations of the molecular mechaNIsms underlying quorum sensing are leading to the development of novel strategies to interfere with quorum sensing. These strategies form the basis of new therapies to be used as antibiotics. See more at http://www.ibioseminars.org
霍乱弧菌群体感应和新型抗生素 - BonNIe Bassler P2
本视频由科普中国和生物医学大讲堂出品
BonNIe Bassler (Princeton) Part 2: Vibrio Cholerae Quorum Sensing and Novel Antibiotics
Bacteria, primitive single-celled orgaNIsms, commuNIcate with chemical languages that allow them to synchroNIze their behavior and thereby act as enormous multi-cellular orgaNIsms. This process is called quorum sensing and it enables bacteria to successfully infect and cause disease in plants, aNImals, and humans. Investigations of the molecular mechaNIsms underlying quorum sensing are leading to the development of novel strategies to interfere with quorum sensing. These strategies form the basis of new therapies to be used as antibiotics. See more at http://www.ibioseminars.org
病毒与宿主细胞表面结合的方式 - Ari HeleNIus P1
本视频由科普中国和生物医学大讲堂出品
Ari HeleNIus (ETH Zurich) Part 1: Virus entry
Viruses are extremely simple and small yet they are responsible for many of the worlds diseases. A virus particle consists of only a genome, a protein coat or capsid, and sometimes a surrounding lipid envelope. To replicate, a virus must successfully enter a host cell, uncoat its genome, and appropriate the host cell machinery to replicate its genome and produce viral proteins. Part 1 of this lecture will discuss ways in which viruses bind to the surface of host cells. Simian Virus 40 which binds to specific cell surface glycolipids, and Human Papilloma Virus-16 which binds to sites on filoipodia, are examples of different binding mechaNIsms. Attachment of viruses to the plasma membrane activates cell signaling resulting in endocytosis of the viral particles. This lecture is appropriate for upper level undergraduate and graduate classes studying virology or endocytosis.