Study the pathological features of diseases using induCEd pluripotent stem CElls derived form patient's somatic CElls
The limited experimental acCEss to disease-affected human tissues has severely impeded the elucidating of molecular mechanisms underlying disease development. Generation of induCEd pluripotent stem CElls (iPSCs) by over-expression of defined transcription factors in somatic CElls, in particular in those from patient somatic CElls, presents an attractive and promising approach to model the early stages of diseases in vitro and to screen novel biomarkers as well as therapeutic medicines. ReCEntly, many research groups have independently reported that patient-specific iPSC-derived CElls recapitulated multiple features of pathological events of a particular disease, offering experimental evidenCE of utilizing patient-specific iPSCs to model diseases and reevaluate the current therapies. We have derived iPSC lines using somatic CElls of patients suffering from Klinefelter's Syndrome (KS) and Alzheimer's Disease (AD) and explored the possibility to use these iPSC lines to recapitulate the pathological features of the diseases. Our results show that patient's specific iPSC lines provide good opportunity to study the development and treatment of diseases.
sRNA InduCEs the Large-scale Transdetermination of Mesenchymal Stem CElls into Hematopoietic Stem CElls in Human.
Mesenchymal stem CElls (MSCs) can differentiate into CElls of bone, endothelium, adipose tissue, cartilage, muscle, and brain. However, whether they can transdeterminate into hematopoietic stem CElls (HSCs) remains unsolved. We report here that a subpopulation of human MSCs that are CD44+,CD29+, CD105+, CD166+,CD133-,CD34- could differentiate into hematopoietic stem CElls (CD150+/CD133+/CD34+) and their desCEnding blood CElls in vitro, when transfected with new endogenous shRNAs The sRNA was high-effectively delivered into MSCs by a novel peptide means. These induCEd MSC-HSCs could form different types of hematopoietic colonies as nature-occurring HSCs did. Upon transplantation into sublethally irradiated NOD/SCID miCE, these MSC-HSCs engrafted and differentiated into all hematopoietic lineages such as erythrocytes, lymphocytes, myelocytes and thrombocyte. More importantly, these induCEd HSCs could sucCEssfully engraft and effectively function in patients with severe aplastic anemia. Furthermore, we demonstrated the first evidenCE that the transdetermination of MSCs was induCEd by aCEtylation of histone proteins and activation of many transcriptional factors. Together, our findings identify the sRNAs that dictates a directed differentiation of MSCs toward HSCs and open up a new sourCE for HSCs used for the treatment of blood diseases and artificial stem CEll-made blood.
The Inner Life of the CEll
由哈佛大学制作的专业视频，描述了从细胞连接、细胞的运动到细胞膜的结构与功能，从细胞骨架到胞内物质的运输，从蛋白质合成到运输与分泌等等，揭示了生命的强大和奇妙。
高内涵分析和筛选InCEll 6000
高内涵技术的领先者IN CEll Analyzer 6000 是以激光为荧光光源的共聚焦成像分析系统，满足更高的高内涵分析和筛选。全新的设计理念搭载独有的专利的可变的共聚焦光阑和新一代科研级sCMOS技术，提供成像速度和图像质量的最优化组合，能够满足几乎所有的专注于细胞模型的基础研究和药物筛选。
InCEll用于心脏毒副作用研究
心脏毒副作用研究已经是药物开发和上市的重要指标。
GE Healthcare推出的高内涵分析系统IN CELL Analyzer搭载生物相关性更好的人胚胎干细胞源心肌细胞为筛选新化合物潜在心脏毒副作用，更早地了解它们的毒性机理提供了一种灵敏有效的方法。
本录像将带您体验HCA的强大分析性能。
HerCEptin Biosimilar GB221（1）
本课程主要讲述了HerCEptin Biosimilar GB221在澳大利亚的1期临床试验的试验背景，相似性研究结果：N-端序列分析，C-端系列分析，色谱分析，等电点，SE-HPLC纯度比较，CE-SDS纯度比较，CEX电荷异构体比较，N-糖分析和比较，亲和力比较，对BT474细胞增殖抑制作用，GB221体外活性比较，GB221药物作用机制研究等一系列知识讲座。
immunotherapy against canCErs(position of sellular therapy)
Study the pathological features of diseases using induCEd pluripotent stem CElls derived form patient's somatic CElls
The limited experimental acCEss to disease-affected human tissues has severely impeded the elucidating of molecular mechanisms underlying disease development. Generation of induCEd pluripotent stem CElls (iPSCs) by over-expression of defined transcription factors in somatic CElls, in particular in those from patient somatic CElls, presents an attractive and promising approach to model the early stages of diseases in vitro and to screen novel biomarkers as well as therapeutic medicines. ReCEntly, many research groups have independently reported that patient-specific iPSC-derived CElls recapitulated multiple features of pathological events of a particular disease, offering experimental evidenCE of utilizing patient-specific iPSCs to model diseases and reevaluate the current therapies. We have derived iPSC lines using somatic CElls of patients suffering from Klinefelter's Syndrome (KS) and Alzheimer's Disease (AD) and explored the possibility to use these iPSC lines to recapitulate the pathological features of the diseases. Our results show that patient's specific iPSC lines provide good opportunity to study the development and treatment of diseases.
JSR Life ScienCEs诊断试剂原料
诊断试剂原料类产品包括：诊断试剂用原料（乳胶微球、磁性粒子、封闭剂）、研究用材料试剂（超常磁珠、粒子和功能配体）、和标准离子。主要用于诊断试剂的研发与生产、蛋白质与核酸的分离、微粒子计数器的校正等。
JSR Life ScienCEs业务介绍
捷时雅（上海）商贸有限公司是JSR 集团在中国的全资子公司，其生物技术部全面负责JSR Life ScienCEs公司及其控股子公司的生物工艺器材、诊断试剂原料和医用高分子材料等产品在中国的市场推广、销售和技术支持工作。生物工艺器材类产品包括：亲和层析填料（protein A 亲和填料）、离子交换层析膜（NatriFlo HD-Q)、三维细胞培养耗材及试剂（SCIVAX)等，主要用于新药候选物筛选、药物毒性评估、生物医药工业的下游分离和纯化及大规模制备生产等领域；