Regenerative medicine for BRain and nerve repair
We isolated and propagated neural stem cells from the exposed BRain tissue of the patients with open BRain trauma, and then implanted neural stem cells with MRI-guided stereotactic device for the patients. Within 2-years follow-ups, the patients were investigated for functional recovery. Contrast to the case control group, implantation of neural stem cells was associated with a significant improvement in patient's neurological function. Investigations of stem cell therapy have required analysis of the fate and migration of implanted neural stem cells. Here, We demonstrate the feasibility of labeling human neural stem cells and retinal stem cells with nanoparticle and tracking of implanted cells in monkey and human central nervous system (CNS). This data demonstrates the possibility of stem cell therapy in CNS and collectively provide necessary foundation for overcoming challenges to the enhancement of translational regenerative medicine of BRain and optic nerve injury.
Regenerative medicine for BRain and nerve repair
We isolated and propagated neural stem cells from the exposed BRain tissue of the patients with open BRain trauma, and then implanted neural stem cells with MRI-guided stereotactic device for the patients. Within 2-years follow-ups, the patients were investigated for functional recovery. Contrast to the case control group, implantation of neural stem cells was associated with a significant improvement in patient's neurological function. Investigations of stem cell therapy have required analysis of the fate and migration of implanted neural stem cells. Here, We demonstrate the feasibility of labeling human neural stem cells and retinal stem cells with nanoparticle and tracking of implanted cells in monkey and human central nervous system (CNS). This data demonstrates the possibility of stem cell therapy in CNS and collectively provide necessary foundation for overcoming challenges to the enhancement of translational regenerative medicine of BRain and optic nerve injury.
Dave deBRonkart：所有病人应彼此交流
当Dave deBRonkart了解到他得了一种罕见的晚期癌症，他在网上向和他一样的一群病人求助，并且找到了一种甚至他自己的医生都没听过的治疗方法。这救了他的命。 现在他号召所有的病人彼此交流，了解自身的健康数据，使医疗事业在每个e-病人的基础上变得更好。
BRCA基因检测--陈巍学基因（16）
BRCA基因是什么？自从美国著名女影星安吉丽娜.朱莉宣布,在体检中她发现自己有BRCA1基因突变,所以她选择做乳腺切除手术,然后又做了卵巢切除手术,自此,BRCA1和BRCA2这两个基因就一夜之间名声大噪。<BR><BR> 本节课程将为您介绍BRCA1和BRCA2基因的检测。
金颖：Fox3 suppresses NFAT-mediated differentiation to maintain self-renewal of emBRyonic stem cells
金颖教授为分子发育生物学研究室主任，健康科学中心研究员。金教授介绍了Fox3通过抑制NFAT介导的分化维持了胚胎干细胞的自我更新的机制等前沿发现。<BR><BR>Pluripotency-associated transcription factor Foxd3 is required for maintaining pluripotent cells. However, molecular mechanisms underlying its function are largely unknown. <BR><BR>Here, we report that Foxd3 suppresses differentiation induced by Calcineurin-NFAT signaling to maintain the ESC identity. Mechanistically, Foxd3 interacts with NFAT proteins and recruits co-repressor Tle4, a member of the Tle suppressor family highly expressed in undifferentiated ESCs, to repress NFATc3’s transcriptional activities. <BR><BR>Furthermore, global transcriptome analysis shows that Foxd3 and NFATc3 co-regulate a set of differentiation-associated genes in ESCs. Collectively, our study establishes a molecular and functional link between a pluripotency-associated factor and an important ESC differentiation-inducing pathway.
BRAF基因与黑色素瘤 - 陈巍学基因（38）
BRAF基因是细胞增殖信号调控中重要的一环。BRAF V600E突变是黑色素瘤中出现频率很高的致癌基因突变。威罗菲尼、达拦菲尼等靶向药物可以治疗有V600E突变黑色素瘤，但长期使用会产生耐药。本视频介绍了相关的知识。
BRain Connectomics
在第3部分，Lichtman询问是否有一天它可能地图上所有的神经连接在大脑中。他描述了允许他的技术进步他的同事们开始这一努力，以及巨大的挑战破译大脑的连接体。
告别BRadford法，全球首台红外光谱仪，检测蛋白含量
Direct DetectTM是全球第一台基于红外原理的生物分子样本定量分析系统，只需要2微升样本以及空白对照（Blank），就可以直接获取结果。无需样本准备，无需比色杯，绝无废液。 Direct DetectTM系统直接基于蛋白长链中的氨基区域在红外吸收光谱分析，无需考虑氨基酸的组成、染料性质、氧化还原电位这些因素，避免了比色法分析的缺陷，可以获得更加准确的结果。 蛋白、脂肪、碳水化合物以及核酸都有可被区分的特定红外吸收光谱，所以您可以很轻松实现复杂混合物各种组分浓度的准确分析。
林鑫华：含UBR-box的E3连接酶在发育中的作用
介绍了发育过程中关键的形态发生素，UBR家族，UBR-box的E3连接酶在发育中的作用，提到了开始研究的一些背景等。