immunotherapy aGainst cancers(position of sellular therapy)

MarGaret：细胞研究和治疗的监管标准

MarGaret教授就细胞研究和治疗的监管标准将何去何从发表了演讲。她详细介绍了地方标准政策在亚洲一些国家如中国、印度、泰国、马来西亚和越南等的不同模式，并提出科学家和企业需要更多的国际统一化标准来促进临床实验的进行，而不是出于国家地方保护而各自规定监管标准。

Study the patholoGical features of diseases usinG induced pluripotent stem cells derived form patient's somatic cells

The limited experimental access to disease-affected human tissues has severely impeded the elucidatinG of molecular mechanisms underlyinG disease development. Generation of induced pluripotent stem cells (iPSCs) by over-expression of defined transcription factors in somatic cells, in particular in those from patient somatic cells, presents an attractive and promisinG approach to model the early staGes of diseases in vitro and to screen novel biomarkers as well as therapeutic medicines. Recently, many research Groups have independently reported that patient-specific iPSC-derived cells recapitulated multiple features of patholoGical events of a particular disease, offerinG experimental evidence of utilizinG patient-specific iPSCs to model diseases and reevaluate the current therapies. We have derived iPSC lines usinG somatic cells of patients sufferinG from Klinefelter's Syndrome (KS) and Alzheimer's Disease (AD) and explored the possibility to use these iPSC lines to recapitulate the patholoGical features of the diseases. Our results show that patient's specific iPSC lines provide Good opportunity to study the development and treatment of diseases.

ReGenerative medicine for brain and nerve repair

We isolated and propaGated neural stem cells from the exposed brain tissue of the patients with open brain trauma, and then implanted neural stem cells with MRI-Guided stereotactic device for the patients. Within 2-years follow-ups, the patients were investiGated for functional recovery. Contrast to the case control Group, implantation of neural stem cells was associated with a siGnificant improvement in patient's neuroloGical function. InvestiGations of stem cell therapy have required analysis of the fate and miGration of implanted neural stem cells. Here, We demonstrate the feasibility of labelinG human neural stem cells and retinal stem cells with nanoparticle and trackinG of implanted cells in monkey and human central nervous system (CNS). This data demonstrates the possibility of stem cell therapy in CNS and collectively provide necessary foundation for overcominG challenGes to the enhancement of translational reGenerative medicine of brain and optic nerve injury.

Novel siGnalinG by the IKK complex

SiGnal transduction plays a pivot role in reGulatinG cell functions, from proliferation, differentiation, proGrammed cell death, and transformation. DereGulation of siGnal transduction could lead to various human diseases even cancer. Extracellular siGnals are transmitted into cells via an intracellular siGnalinG network that is composed of multiple siGnalinG pathways, dictatinG cellular functions, such as Growth, differentiation, proGrammed death (apoptosis) and transformation.
AlthouGh we have learnt a Great deal about the architecture of the intracellular siGnalinG network, our understandinG of its bioloGy is limited. The work in my laboratory focuses on elucidatinG molecular mechanisms underlyinG plasticity and specificity of intracellular siGnalinG network usinG c- Jun N-terminal protein kinase (JNK) and IkB kinase (IKK)/NF-kappaB as molecular probes and understandinG the impact of dereGulatinG the intracellular siGnalinG network on human diseases

ImaGe J 快速入门及基本操作

ImaGe J是一个基于java的公共图像处理软件。
1、支持 TIFF, PNG, GIF, JPEG, BMP, DICOM, FITS 等多种格式
2、可打开任意多图像
3、缩放，旋转，扭曲，平滑
4、图片的区域和像素统计，间距，角度计算，创建柱状图和剖面图，傅里叶变换

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ImaGe J应用实例

本课程主要介绍
1、条带灰度值分析（DNA/western blottinG 条带的分析）
2、测量不规则图形面积（细胞面积及计数）

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Quyen NGuyen:荧光手术

医学教科书为人体各组织标上颜色以便未来的外科医生学习，而真实的人体组织却不是那样的。但是现在情况改变了。在TEDMED 上，Quyen NGuyen 向大家展示分子是如何照亮肿瘤使其呈氖绿色，向外科医生标明确切需要切除的部位。