端粒和端粒酶的作用 - Elizabeth Blackburn P1
本视频由科普中国和生物医学大讲堂出品
Elizabeth Blackburn (UCSF) Part 1: The Roles of Telomeres and Telomerase
Lecture Overview
Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative studies have shown the relationship between accelerated telomere shortening and life stress and that low telomerase levels are associated with six prominent risk factors for cardiovascular disease.
端粒和端粒酶在人类干细胞和癌症中的作用 - Elizabeth Blackburn P2
本视频由科普中国和生物医学大讲堂出品
Elizabeth Blackburn (UCSF) Part 2: Telomeres and Telomerase in Human Stem Cells and in Cancer
Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative studies have shown the relationship between accelerated telomere shortening and life stress and that low telomerase levels are associated with six prominent risk factors for cardiovascular disease.
高维强：前列腺癌异质性的新认识：端粒酶活性、肿瘤干细胞及细胞分裂模式的作用
介绍了在半数胃癌肿瘤患者突变的p53基因，肿瘤异质性的形成机制。肿瘤干细胞治疗策略，提到了肿瘤干细胞的特性及研究手段，临床前列腺癌符合肿瘤干细胞理论、介绍了端粒酶的研究背景和最新进展，提到了与衰老相关的重要概念。端粒酶与前列腺干细胞分裂模式及前列腺癌恶化。