朱宝利:肠道微生物对人类健康的意义-第4段
介绍了肠道微生物在人类健康中扮演的角色,产生维生素、调控新陈代谢和储存营养、帮助消化吸;如何保护人体健康,与病原微生物竞争资源、产生抗生素、改变人体外环境等内容……
细胞囊泡萌芽与人类健康
Randy Schekman (Berkeley) Part 3: Human Diseases of Vesicle Budding
Human COPII genes are duplicated and some may have evolved specialized functions. Two rare human diseases affect the activity of one of two copies of Sar1 and the Sec23A subunit of the COPII coat. Anderson's disease results in the failure of enterocytes of the absorptive epithelium to secrete large lipoprotein particles called chylomicrons. Point mutations in one of two copies of Sar1 results in the accumulation of chylomicrons in the ER. CLSD, a rare craniofacial disorder likely due to the selective failure of secretion of certain connective tissue proteins such as collagen, is caused by a conservative amino acid substitution in Sec23A that blocks completion of COPII coat assembly. See more athttp://www.ibioseminars.org