Controlling the Cell Cycle: Introduction - David O. Morgan
本视频由科普中国和生物医学大讲堂出品
David O. Morgan (UCSF) Part 1: Controlling the Cell Cycle: Introduction
Cells reproduce by duplicating their chromosomes and other components and then distributing them into a pair of genetically identical daughter cells. This series of events is called the cell cycle. In the first part of this lecture, I provide a general overview of the cell-cycle control system, a complex regulatory network that guides the cell through the steps of cell division. I briefly describe the major components of this regulatory system and how they fit together to form a series of biochemical switches that trigger cell-cycle events at the correct time and in the correct order.
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Controlling the Cell Cycle: Cdk Substrates - David O. Morgan
本视频由科普中国和生物医学大讲堂出品
David O. Morgan (UCSF) Part 2: Controlling the Cell Cycle: Cdk Substrates
Cyclin-dependent kinases (Cdks) are the central components of the control system that initiates the events of the cell cycle. In the second part of this lecture, I discuss my laboratory's efforts to address the problem of how the Cdks trigger cell-cycle events. I describe our methods for identifying the protein substrates of the Cdks, and I discuss how these studies have led to important clues about how Cdks find their correct targets in the cell and how phosphorylation of those targets governs their function.
Controlling the Cell Cycle: Anaphase Onset - David O. Morgan
本视频由科普中国和生物医学大讲堂出品
David O. Morgan (UCSF) Part 3: Controlling the Cell Cycle: Anaphase Onset
In the anaphase stage of the cell cycle, the duplicated chromosomes are pulled apart by a machine called the mitotic spindle, resulting in the distribution of a complete set of chromosomes to each of the daughter cells. In the third part of this lecture, I describe the combination of biochemistry and microscopy in my laboratory that led to the discovery of a regulatory switch that triggers the abrupt and synchronous separation of the chromosomes at the onset of anaphase.
Photoreceptors and Image Processing Part 1A - Jeremy Nathans
本视频由科普中国和生物医学大讲堂出品
Jeremy Nathans (Johns Hopkins) Part 1A: Photoreceptors and Image Processing
In this set of lectures, Jeremy Nathans explores the molecular mechanisms within the retina that mediate the first steps in vision. The first lecture focuses on the structure of the light sensing receptors, the intracellular signals that are triggered by light absorption, and the ways in which the retina extracts information from a complex scene. See more at http://www.ibioseminars.org
Photoreceptors and Image Processing Part 1B - Jeremy Nathans
本视频由科普中国和生物医学大讲堂出品
Jeremy Nathans (Johns Hopkins) Part 1B: Photoreceptors and Image Processing
In this set of lectures, Jeremy Nathans explores the molecular mechanisms within the retina that mediate the first steps in vision. The first lecture focuses on the structure of the light sensing receptors, the intracellular signals that are triggered by light absorption, and the ways in which the retina extracts information from a complex scene. See more at http://www.ibioseminars.org
【视频教程】揭开exoRNA的神秘面纱
RNA曾被认为只存在于细胞之中，在转录与翻译中起桥梁作用，但最新的研究发现，胞外囊泡外泌体中的RNA（exoRNA）可以经胞外囊泡外泌体转运到其他细胞中并发挥调节作用。让我们一起来透过视频介绍，揭开exoRNA的神秘面纱吧！
Unlocking the Mysteries of extracellular RNA Communication
Once thought to exist only inside cells, RNA is now known to travel outside of cells and play a role in newly discovered mechanisms of cell-to-cell communication. Are these extracelluar RNAs (exRNAs) involved in diseases like cancer, heart disease or neurological diseases like Alzheimer's? Could scientists learn how to use exRNAs to diagnose diseases earlier or even to treat these diseases? The NIH Common Fund's extracellular RNA Communication program aims to unlock the mysteries of exRNAs, uncovering their roles in human health and disease.
布鲁斯·艾伯茨：Learning from Failure
Alberts declares "Success doesn't really teach you much, failure teaches you a lot." Speaking from his personal experience, Alberts asserts that all scientists make mistakes and suffer setbacks but learning from those failures is what allows one ultimately to succeed.
用血小板RNA-seq测肿瘤 - 陈巍学基因（33）
Myron G. Best 等人发现，可以用血小板RNA-seq测序结合生物信息学分析，很好地判断： 1、一个人是否患有肿瘤； 2、是患的哪种肿瘤； 3、肿瘤中有哪些突变。 本视频介绍了这项发现的成果、实验方法、分析思路。
RNAscope®技术原理介绍
RNAscope®®原位定量专利技术由美国新兴的分子病理领导者ACD公司(Advanced Cell Diagnostics, Inc., California, USA)开发，通过专利的双“Z”探针设计，使RNA原位杂交具有高度特异性、单分子检测的敏感性并有极高的信噪比，能够在单细胞水平同时定量多个RNA的表达，在获得单细胞中单拷贝RNA表达数据的同时提供完整的组织形态学信息，提高对疾病与标志物之间复杂的生物学相关性的认识，是理想的能够用于NGS和芯片技术后期转化研究技术平台。
自2011年技术推广以来,其应用已在如Nature、Science、NeJM等国际顶级期刊发表超过300篇SCI论文。研究涵盖了感染及免疫、肿瘤、神经生物学、干细胞及发育、非编码RNA、表观遗传学等基础医学领域，以及靶标鉴别和验证、临床前安全性评价和药效评估等药物开发研究。
请访问ACD官网www.acdbio.com。更多中文资料与信息请访问中国官方微信号（ACD_China）咨询。
将RNAscope®技术应用于病毒学的研究
Advanced Cell Diagnostics邀请了美国加利福尼亚大学（Davis）微生物、免疫及病理学系教授Patricia Pesavento，为大家介绍应用RNAscope®技术在研究新发现的病毒及致病病因、病理方面的研究。引起疾病的病毒可以跨越种族感染，通过测序发现新型病毒，利用RNAscope®进行病毒病理学分析，以准确判断疾病及复杂的宿主病毒相互影响。在这一讲座中，Pesavento教授以乳头瘤病毒等举例，对病毒的潜伏、致瘤和急性裂解细胞分析，分享了病毒学的研究进展。
RNAscope®技术可以针对任一病毒（或亚型）序列设计特异性探针，通过原位定量检测获得病毒感染、潜伏及与宿主反应的研究信息。详细信息请访问ACD官网www.acdbio.com。更多中文资料请关注中国官方微信号（ACD_China）咨询。