RegenERAtive medicine for brain and nerve repair

We isolated and propagated neural stem cells from the exposed brain tissue of the patients with open brain trauma, and then implanted neural stem cells with MRI-guided stereotactic device for the patients. Within 2-years follow-ups, the patients were investigated for functional recovery. Contrast to the case control group, implantation of neural stem cells was associated with a significant improvement in patient's neurological function. Investigations of stem cell thERApy have required analysis of the fate and migration of implanted neural stem cells. Here, We demonstrate the feasibility of labeling human neural stem cells and retinal stem cells with nanoparticle and tracking of implanted cells in monkey and human central nervous system (CNS). This data demonstrates the possibility of stem cell thERApy in CNS and collectively provide necessary foundation for overcoming challenges to the enhancement of translational regenERAtive medicine of brain and optic nerve injury.

immunothERApy against cancers(position of sellular thERApy)

RegenERAtive medicine for brain and nerve repair

We isolated and propagated neural stem cells from the exposed brain tissue of the patients with open brain trauma, and then implanted neural stem cells with MRI-guided stereotactic device for the patients. Within 2-years follow-ups, the patients were investigated for functional recovery. Contrast to the case control group, implantation of neural stem cells was associated with a significant improvement in patient's neurological function. Investigations of stem cell thERApy have required analysis of the fate and migration of implanted neural stem cells. Here, We demonstrate the feasibility of labeling human neural stem cells and retinal stem cells with nanoparticle and tracking of implanted cells in monkey and human central nervous system (CNS). This data demonstrates the possibility of stem cell thERApy in CNS and collectively provide necessary foundation for overcoming challenges to the enhancement of translational regenERAtive medicine of brain and optic nerve injury.

Targets-based thERApy for leukemia: opportunity and challenge

优点主要为：能增强患者的免疫力，防止肿瘤的转移和复发，对病人机体的损伤小。 在我国，现在普遍开展的树突状细胞（DC）和细胞因子诱导的杀伤细胞（CIK）的生物疗法被广泛应用。

Erich Gnaiger：Life Style and Mitochondrial Competence – Modern Drugs for T2 Diabetes in Aging and DegenERAtive Diseases.

D. Swarovski Research Laboratory (Mitochondrial Physiology), Dept. GenERAl, ViscERAl and Transplant Surgery, Innsbruck Medical University; and OROBOROS INSTRUMENTS, Innsbruck, Austria. - Email: erich.gnaiger@oroboros.at

The contribution of mitochondrial dysfunction to the etiology of T2 diabetes and a range of preventable metabolic diseases is the subject of intensive current research with world-wide health implications.

Recently these investigations gained depth and scope by technological advances for diagnosis of mitochondrial function by comprehensive OXPHOS analysis using high-resolution respirometry [1,2]. Fundamental questions of a causal relationship, however, between compromised mitochondrial function and development of T2 diabetes remain to be resolved [3,4] to optimize prevention and treatment of insulin resistance.

For preventable diseases such as T2 diabetes, the evolutionary background of mitochondrial competence provides a solid basis for improved and broad application of a well established modern drug, mtLSD.

Post-industrial societies are characterized by a high-energy input lifestyle with diminished physical activity and high incidence of non-transmittable diseases, in comparison to human populations where physical work is essentially important for sustaining life and in which degenERAtive diseases (T2 diabetes, various cancers, Alzheimer's) are essentially absent [5]. The capacity of oxidative phosphorylation (OXPHOS) is increased or maintained high by a life style involving endurance exercise and strength training [6].

Life style changes from the age of 20-30 years to the elderly, but is subject to change and intervention. Depending on group selection in cross-sectional studies, OXPHOS capacity declines from the age of 20-30 years [7,8], or is independent of age up to 80 years [9,10].

Independent of age, there is a strong decline of OXPHOS capacity in human vastus latERAlis from BMI of 20 to 30 [1]. At a BMI >30, a threshold OXPHOS capacity is reached in human v. latERAlis that may be characteristic of a low-grade inflammatory state (‘mitochondrial fever’).

Onset of degenERAtive diseases (T2 diabetes, neuromuscular degenERAtion, various cancers) and mitochondrial dysfunction intERAct in an amplification loop progressing slowly with age, such that cause and effect of mitochondrial dysfunction cannot be distinguished. Diminished antioxidant capacity at low mitochondrial density is an important mechanistic candidate in the state of mitochondrial fever.

For implementing a life style supporting mitochondrial competence and preventing degenERAtive diseases in modern societies, we need (1) extended research programmes focused on the causative link between mitochondrial competence and effective prevention of degenERAtive diseases, (2) educational programmes on mitochondrial physiology targeted at genERAl practitioners, teachers and the society at large, (3) coopERAtion of health care and insurance organizations to support preventive life style activities, and (4) do not miss any opportunity in taking the lead in living the mtLife Style Drug (mtLSD).

GenERAting B-lymphoblastoid cell lines using Epstein Barr virus transformation.

GenERAting immortalized B-lymphoblastoid cell lines via Epstein Barr virus transformation using the B95-8 EBV-infected and producing marmoset cell line.

Introducing the OpERA Phenix™ High Content Screening System

Introducing OpERA Phenix™, a next-genERAtion, confocal, high content screening system designed for high-throughput, phenotypic screening and assays using complex disease models, such as primary cells and microtissues. Find out more at http://bit.ly/1eZM4Ok.

Evolution of intERAction networks 相互作用网络的演化

为什么一些殖民地饲料少：蚂蚁作为神经元？蚂蚁是如何反应的互动率？ 蚂蚁对相互作用的遗传变异？跟随专注研究蚂蚁殖民地发展行为的戈登，了解蚁群的两大问题：1、节约用水，2、同种的邻居竞争。