剪接体的结构和动力学 - Melissa Moore Part 2
本视频由科普中国和生物医学大讲堂出品
本节课Melissa Moore讲述了，剪接体的成分和在每个工作周期中的剪接体。穆尔还解释了如何利用荧光蛋白标签和全反射显微镜的创新，使她和她的同事们能够更好地理解复接机器的有序组装与功能。
Melissa Moore (U. Mass/HHMI) Part 2: Spliceosome Structure and Dynamics
Moore goes on to describe the cellular splicing machine, the spliceosome, in greater detail in Part 2. She lists the components of the spliceosome and where each works in the spliceosome cycle. Moore also explains how the innovative use of fluorescent protein tags and total internal reflection microscopy has allowed her and her colleagues to better understand the ordered assembly and function of the complex splicing machine.
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我是如何成为一名科学家的 - Alfredo Quinones-Hinojosa
本视频由科普中国和生物医学大讲堂出品
Alfredo Quinones-Hinojosa（Q博士）（霍普金斯达大学）：我是如何成为一名科学家
出生于墨西哥的Q博士，19岁时翻越美国边界的栅栏，成为加利福尼亚的一名农场工人。由于他自己的决心，努力工作和自律，以及来自家庭和朋友的大量支持，他离开了农场工作，完成了大学和医学院的学业，最终成为一位非常成功的医生、科学家和脑外科医生。
关于讲师：Alfredo Quinones-Hinojosa是约翰霍普金斯大学，神经外科学和肿瘤学，神经系统的细胞与分子医学的副教授，脑肿瘤外科手术的主任。Q博士作为一个专家外科医生，他致力于干细胞，在脑肿瘤的病因和治疗领域的研究。
Alfredo Quinones-Hinojosa (Dr. Q) (Johns Hopkins): How I Became a Scientist
At age 19, Quiñones-Hinojosa jumped the fence from Mexico to become a farm worker in California. Thanks to his own determination, hard work and discipline and a lot of support from family and friends, he left farm work, completed university and medical school, and ultimately became a highly successful physician-scientist and brain surgeon.
About the speaker: Alfredo Quiñones-Hinojosa is an Associate Professor of Neurosurgery and Oncology, Neuroscience and Cellular and Molecular Medicine and Director of the Brain Tumor Surgery Program at Johns Hopkins University. As well as being an expert surgeon, he researches the role of stem cells both in causing brain tumors and potentially in fighting them.
This talk was first released in iBioMagazine Issue 5.
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Controlling the Cell Cycle: Introduction - David O. Morgan
本视频由科普中国和生物医学大讲堂出品
David O. Morgan (UCSF) Part 1: Controlling the Cell Cycle: Introduction
Cells reproduce by duplicating their chromosomes and other components and then distributing them into a pair of genetically identical daughter cells. This series of events is called the cell cycle. In the first part of this lecture, I provide a general overview of the cell-cycle control system, a complex regulatory network that guides the cell through the steps of cell division. I briefly describe the major components of this regulatory system and how they fit together to form a series of biochemical switches that trigger cell-cycle events at the correct time and in the correct order.
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科学启蒙的回馈 - 安德鲁·穆雷
许多科学家之所以走上科研的道路，是因为他们遇到了一位充满热情，富有灵感的好老师，
穆雷认为，我们应该懂得回馈，就像我们敬爱的老师一样，在科学的路上帮助和启蒙更多人。当然，也会有其他更自私的原因，包括吸引优秀的学生到你的实验室，以及能够在宴会上，向你遇到的某人，展示你真的做了什么。
Giving Back: Andrew Murray (Harvard University)
Many scientists became scientists because they were influenced by an inspirational teacher. Murray argues that while this should be reason enough to teach, there are also other, more selfish, reasons. These include attracting good students to your lab, as well as being able to explain to someone you meet at a cocktail party what it is that you really do.
Controlling the Cell Cycle: Cdk Substrates - David O. Morgan
本视频由科普中国和生物医学大讲堂出品
David O. Morgan (UCSF) Part 2: Controlling the Cell Cycle: Cdk Substrates
Cyclin-dependent kinases (Cdks) are the central components of the control system that initiates the events of the cell cycle. In the second part of this lecture, I discuss my laboratory's efforts to address the problem of how the Cdks trigger cell-cycle events. I describe our methods for identifying the protein substrates of the Cdks, and I discuss how these studies have led to important clues about how Cdks find their correct targets in the cell and how phosphorylation of those targets governs their function.
Controlling the Cell Cycle: Anaphase Onset - David O. Morgan
本视频由科普中国和生物医学大讲堂出品
David O. Morgan (UCSF) Part 3: Controlling the Cell Cycle: Anaphase Onset
In the anaphase stage of the cell cycle, the duplicated chromosomes are pulled apart by a machine called the mitotic spindle, resulting in the distribution of a complete set of chromosomes to each of the daughter cells. In the third part of this lecture, I describe the combination of biochemistry and microscopy in my laboratory that led to the discovery of a regulatory switch that triggers the abrupt and synchronous separation of the chromosomes at the onset of anaphase.
Photoreceptors and Image Processing Part 1A - Jeremy Nathans
本视频由科普中国和生物医学大讲堂出品
Jeremy Nathans (Johns Hopkins) Part 1A: Photoreceptors and Image Processing
In this set of lectures, Jeremy Nathans explores the molecular mechanisms within the retina that mediate the first steps in vision. The first lecture focuses on the structure of the light sensing receptors, the intracellular signals that are triggered by light absorption, and the ways in which the retina extracts information from a complex scene. See more at http://www.ibioseminars.org
Photoreceptors and Image Processing Part 1B - Jeremy Nathans
本视频由科普中国和生物医学大讲堂出品
Jeremy Nathans (Johns Hopkins) Part 1B: Photoreceptors and Image Processing
In this set of lectures, Jeremy Nathans explores the molecular mechanisms within the retina that mediate the first steps in vision. The first lecture focuses on the structure of the light sensing receptors, the intracellular signals that are triggered by light absorption, and the ways in which the retina extracts information from a complex scene. See more at http://www.ibioseminars.org
王欣：个体肠道菌群的多样性影响寡糖的降解和利用-46分钟完整版
第1段：肠道菌群对人体健康的影响
已知人类结肠中共存着大约1000到1150种的细菌。每个人的肠道内大约有160种细菌，每个人的肠道菌群都有所不同，这对我们健康有什么影响？
第2段：SFB在回肠末端的定值受到雏鸡年龄的影响
第3段：体外肠道模拟系统
什么是体外肠道模拟系统，以及该模型的可靠性评估，在检测食品和药品肠道吸收方面的作用。主要介绍了单级连续发酵模型，在鸡和人的盲肠菌群试验中的具体应用。
第4段：微生物对糖的转化和降解
海洋寡糖和多糖一直是中国人的传统食品，近年来大量用于食品增稠剂中。本段片介绍了微生物对琼胶寡糖、褐藻胶和卡拉胶这三种海洋寡糖的降解情况。还介绍了Ecoli和Bacteroides-Prevotella菌群的协同作用机理。
第5段：观众提问
王欣：肠道菌群对人体健康的影响-第1段
已知人类结肠中共存着大约1000到1150种的细菌。每个人的肠道内大约有160种细菌，每个人的肠道菌群都有所不同，这对我们健康有什么影响？