颜丙翔：大数据分析与健康保险的结合趋势
1. 保险本身就是大数法则的具体应用
2. 保险公司是大数据的强大采购方
3. 健康保险的基本原理及案例
4. 怎样的结合方式是未来的趋势
病毒与宿主细胞表面结合的方式 - Ari Helenius P1
本视频由科普中国和生物医学大讲堂出品
Ari Helenius (ETH Zurich) Part 1: Virus entry
Viruses are extremely simple and small yet they are responsible for many of the worlds diseases. A virus particle consists of only a genome, a protein coat or capsid, and sometimes a surrounding lipid envelope. To replicate, a virus must successfully enter a host cell, uncoat its genome, and appropriate the host cell machinery to replicate its genome and produce viral proteins. Part 1 of this lecture will discuss ways in which viruses bind to the surface of host cells. Simian Virus 40 which binds to specific cell surface glycolipids, and Human Papilloma Virus-16 which binds to sites on filoipodia, are examples of different binding mechanisms. Attachment of viruses to the plasma membrane activates cell signaling resulting in endocytosis of the viral particles. This lecture is appropriate for upper level undergraduate and graduate classes studying virology or endocytosis.
GTP结合蛋白作为调节分子
When a growth factor binds to the plasma membrane of a quiescent cell, an intracellular signaling pathway is activated telling the cell to begin growing. A key molecule in this signaling pathway is the GTP-binding protein, or G-protein, Ras. Ras can act as an on-off switch telling the cell to grow or not. In its inactive form, Ras is bound to GDP while in its active form it is bound to GTP. This exchange of nucleotides is catalysed by guanine nucleotide-exchange-factors (GEFs). The return to the inactive state occurs through the GTPase reaction, which is accelerated by GTPase-activating proteins (GAPs). In Part 1 of his talk, Dr. Wittinghofer explains how solving the three-dimensional structure of Ras, and other G-proteins, allowed him to understand the conserved mechanism by which G-proteins can act as switches. The structure also identified domains unique to each G-protein that provide the specificity for downstream signals.
饶 枫：多磷酸肌醇信号分子通过介导Cullin-COP9复合体的动态结合调控Cullin酶活
介绍了1. IP6K1介导CRL4A-CSN复合体的组装和UV依赖性组装。2. 肌醇六磷酸（IP6）及其合成酶IPSk介导CR1-CSN相互作用和CRL功能。3. 肌醇六磷酸（IP6）及其合成酶IPSk介导CR1-CSN相互作用和CRL功能。
多维度成像方案与 CRISPR-Cas9 技术结合助力药学研究
多维度成像方案与 CRISPR-Cas9 技术结合助力药学研究 简介：CRISPR-Cas9系统是一种适应性免疫系统，可作为操纵基因组序列的快速、高效、低成本且可扩展的工具。该系统可对活细胞中重复或低重复序列基因位点进行实时多位点同步成像..