涡虫的再生原理
Alejandro Sanchez-Alvarado (Stowers Institute) Part 2: Principles of Planarian Regeneration
Planarians have attracted the attention of generations of biologists. It is not hard to see why: cut a worm into two fragments and each fragment regenerates a complete organism. Cut it into 8 fragments and each individual fragment will go on to regenerate a complete animal. In this second part of the lecture, I will briefly review the rich history of planarian research, followed by a summary of the central principles of planarian regeneration that have been derived from this extensive, often fascinating body of experimental work.
Alejandro Sánchez Alvarado moved from the University of Utah to the Stowers Institute for Medical Research in 2011.
在涡虫再生的分子基础
Alejandro Sanchez-Alvarado (Stowers Institute) Part 3: Molecular Basis of Regeneration in Planaria
In the third and last part of this lecture, I will introduce the model system we have developed to study animal regeneration, the planarian Schmidtea mediterranea. I will review its anatomy, and the biological attributes that make these animals extraordinarily well suited to dissect the molecular and cellular basis of regeneration. I will also discuss recent work from my laboratory aimed at identifying molecules associated with regenerative capacities.
Alejandro Sánchez Alvarado moved from the University of Utah to the Stowers Institute for Medical Research in 2011.
未分化细胞：涡虫的干细胞
自由生活的涡虫是扁形动物最有名的惊人能力从一小块组织中再生一个完整的有机体和“收缩”的能力，通过丢失的细胞，在饥饿。在他的第二个视频的á桑切斯Alvarado重点neoblasts，涡虫的干细胞。通过确定遗传标记每个阶段的干细胞分化（前，早，晚和端差终末分化），Sá桑切斯Alvarado的实验室能够证明干细胞是真正的全能性，从而产生各种细胞类型。令人惊讶的是，他们还展示了第一次涡虫neoblasts经历acentriolar分裂，一个过程，已知的只有细胞减数分裂期间发生在动物细胞分裂。