我们的自然睡眠周期
当今世界中，我们要在学校、工作、孩子及其他事项中保持平衡，我们中多数的人都无法达到推荐的八小时睡眠。杰莎·甘布尔检视了我们身体内生物钟背后的科学，揭示出我们应留意的令人惊讶的实质的休息方案。
细胞质处理小体(P-小体)和mRNA的周期
Roy Parker (U. Colorado Boulder/HHMI) Part 2: P-bodies and the mRNA Cycle
In the second part of this lecture, I will provide an overview of why the regulation of translation and mRNA degradation is an important aspect of the control of gene expression in eukaryotic cells. In addition to the translating pool of mRNAs associated with polysomes, recent experiments have identified P-bodies and stress granules as specific cytoplasmic compartments wherein untranslated mRNAs accumulate. In addition to mRNAs, P-bodies tend to contain translation repressors and mRNA degradative enzymes, while stress granules reflect mRNAs in association with some translation initiation factors and RNA binding proteins. P-bodies and stress granules interact and suggest a dynamic process wherein eukaryotic mRNAs remodel their interacting proteins and enter and exit translation, thereby affecting the control of mRNAs in the cytoplasm. We are interested in defining the mechanisms by which P-bodies and stress granules assemble and how cells regulate the movement of mRNAs between these different biochemical and cell biological compartments. Several approaches will be described including biochemical and genetic analyses of known proteins modulating these events, as well as the identification of new factors affecting P-body and stress granule formation and function.
In 2012, Roy Parker joined the University of Colorado, Boulder after many years at the University of Arizona.
伍会健：泛素化/SUMO化与周期节律及乳腺癌
介绍了p160家族的SUMO化，雌激素信号与乳腺癌的关系，p160机组成员与CLOCK结构对比，CLOCK与ERα间相互作用的确定，提到CLOCK蛋白能被SUMO化修饰，提到发现并鉴定出多个周期节律蛋白等。