生物学中的蛋白质磷酸化 - Susan Taylor
In this lecture, I have given an overview of protein kinase structure and function using cyclic AMP dependent kinase (PKA) as a prototype for this enzyme superfamily. I have demonstrated what we have learned from the overall structural kinome which allows us to compare many protein kinases and also to appreciate how the highly regulated eukaryotic protein kinase has evolved. By comparing many protein kinase structures, we are beginning to elucidate general rules of architecture. In addition, I have attempted to illustrate how PKA is regulated by cAMP and how it is localized to specific macromolecular complexes through scaffold proteins.
饶 枫：多磷酸肌醇信号分子通过介导Cullin-COP9复合体的动态结合调控Cullin酶活
介绍了1. IP6K1介导CRL4A-CSN复合体的组装和UV依赖性组装。2. 肌醇六磷酸（IP6）及其合成酶IPSk介导CR1-CSN相互作用和CRL功能。3. 肌醇六磷酸（IP6）及其合成酶IPSk介导CR1-CSN相互作用和CRL功能。