研究寄生虫的质体，提供药物开发的新靶点
David Roos (U Penn) Part 2: The apicomplexan plastid
Antibiotics are effective because they kill bacteria without harming humans and other eukaryotes (organisms with cells that contain nuclei). So why are the eukaryotic parasites responsible for malaria and toxoplasmosis killed by drugs like clindamycin? Multidisciplinary studies integrating molecular genetics, cell biology, biochemistry, pharmacology and computational genomics reveal that such drugs target an unusual organelle. The "apicoplast" was acquired when an ancestral organism 'ate' a eukaryotic alga, and retained the algal plastid -- a relative of plant chloroplasts derived from a bacterial ancestor. Although no longer photosynthetic, the apicoplast is essential for parasite survival, providing new targets for drug development. See more at http://www.ibioseminars.org
NTRK检测的前世今生，赛默飞提供多种解决方案
近几年，随着基因检测行业的发展，越来越多的针对特定基因突变的 靶向药物被研发出来，临床上同病异治和异病同治的观念也越来越强。针对NTRK融合这种多个癌症类型都会发生的突变，目前已经有相应的FDA批准的药物和正在进行临床试验的药物。但是，相应的检测方案有很多，在NTRK融合检测过程中也遇到了一些挑战。赛默飞在该领域提供了多种解决方案，解决传统检测方案遇到的难题，为患者带来临床生存获益。 本次讲座的内容主要分为三个部分： （1）NTRK融合检测背景介绍，让您更了解NTRK融合检测的前世今生； （2）目前NTRK融合检测遇到的挑战，使您更了解NTRK融合检测存在的问题； （3）赛默飞提供多种NTRK融合检测方案，为临床提供更加精准的解决方案，使患者获益；