Karen Dell: iBiology:Meet the world's best biologists through the Internet
Karen Dell来自美国细胞生物学学会，她将简述通过iBiology来获取生物学学习和交流的资源。
贾立军：Neddylation蛋白修饰-Crl 泛素连接酶通路调控肿瘤细胞自噬应答的机制与潜在应用
贾立军博士，复旦大学附属肿瘤医院肿瘤研究所研究员和博士生导师。目前主要从事“针对蛋白质翻译后修饰通路进行抗肿瘤分子靶点发现”等研究工作。
相关研究在 J Natl Cancer Inst（JNCI）、Cancer Research、Clinical Cancer Research、Autophagy、Cell Death & Differentiation、Cell Death & Disease、Int J Cancer和J Biol Chem等学术期刊发表文章40篇、获邀参编英文专著4部。主持国家自然科学基金（81372196，31071204，30500637，81172092）、国家重大科学研究计划（2012CB910302，课题负责）、上海市卫生局A类重点项目 (2010012)、上海市“浦江人才 ”资助计划（12PJ1400600）和上海高校特聘教授（东方学者）资助计划等科研项目。
学术兼职包括：国家自然科学基金委员会医学科学领域学科评审组专家、中华医学科技奖评审委员会委员、上海市免疫学会肿瘤免疫专业委员会委员、高等学校自然科学奖和技术发明奖评审专家和十余种学术期刊审稿专家。荣获上海高校特聘教授（东方学者）和上海市浦江人才等荣誉称号。
细胞粘附、信号和癌症 - Mary Beckerle P1
本视频由科普中国和生物医学大讲堂出品
Mary Beckerle (University of Utah) Part 1: Adhesion, Signaling and Cancer
Cell-substratum adhesion is mediated by integrins, a family of transmembrane, heterodimeric, extracellular matrix receptors that are concentrated at focal adhesions. Integin engagement influences a variety of signaling pathways and regulates cell behaviors including motility, proliferation, and survival. Disturbance of normal integrin function is associated with a variety of pathologic conditions including cancer. In the first segment of my seminar, I provide a broad overview of the cancer problem for a lay audience. Advances in our understanding of cancer as a genetic disease are discussed. The influence of cell adhesion on control of cell growth is reviewed. See more at http://www.ibiology.org
粘着蛋白的发现和表征 - Mary Beckerle P2
本视频由科普中国和生物医学大讲堂出品
Mary Beckerle (University of Utah) Part 2: Discovery and Characterization
In the second segment, I describe the identification of the focal adhesion protein, zyxin, by my lab. Recent work revealed that zyxin is down-regulated upon expression of the Ewing sarcoma oncoprotein, EWS-FLI. Loss of zyxin expression results in enhanced cell motility and is also associated with failed apoptotic signaling. Evidence that zyxin shuttles between focal adhesions and the nucleus is presented. The impact of reduced zyxin expression on tumor progression is discussed. See more at http://www.ibiology.org
焦点粘连作为压力传感器 - Mary Beckerle P3
本视频由科普中国和生物医学大讲堂出品
Mary Beckerle (University of Utah) Part 3: Focal Adhesions as Stress Sensors
In the third segment of my seminar, I address a new frontier in cell biology, that is how cells respond to mechanical information. Cells and tissues are exposed to physical forces in vivo and excessive mechanical stress leads to a variety of pathological consequences. I describe a system for exposing cells to controlled mechanical stress and discuss the stretch response. We have discovered that the focal adhesion protein, zyxin, is exquisitely sensitive to mechanical stimulation and is required for the ability of cells to reinforce the actin cytoskeleton when challenged by exposure to cyclic stretch. See more at http://www.ibiology.org
仓 勇：通过调节Crl4(CRBN)泛素连接酶的活性增强抗骨髓瘤药物IMiDs的作用
介绍了一个案例以及实验室相关的研究，介绍了通过调节Crl4(CRBN)泛素连接酶的活性增强抗骨髓瘤药物IMiDs的作用。