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JCI:揭秘肥胖和胰腺炎之间的神秘关联

来源:本站原创 2020-03-14 09:32

2020年3月14日 讯 /生物谷BIOON/ --近日,一项刊登在国际杂志Journal of Clinical Investigation上的研究报告中,来自梅奥诊所的研究人员通过研究发现,肥胖或许并不仅仅与诸如糖尿病等慢性疾病有关,而且还与一些突然发病的疾病有关,比如胰腺炎等。

图片来源:Hellerhoff/Wikipedia

研究者Vijay Singh博士表示,这项研究中我们发现,在急性胰腺炎期间腹部的脂肪会快速退化,但在憩室炎(diverticulitis)期间却不会(尽管存在炎症),这两种疾病都会伴随腹部突然疼痛,其每年在美国大约会影响30万名患者的健康;胰腺炎发生期间机体脂肪的快速退化常常是由一种名为PNLIP的胰腺酶类所诱发,该酶能形成脂肪酸从而促进诸如机体循环、肾脏和肺脏功能等关键机体系统失去功能,这种多系统衰竭在急性胰腺炎中要比在憩室炎中更为常见一些。

肥胖会增加腹部脂肪,其同时还会恶化急性胰腺炎的表现,这就凸显了肥胖不仅在慢性疾病的发生(糖尿病)中扮演关键角色,还在胰腺炎等突发疾病的发生中也发挥着重要作用。研究者Singh说道,不饱和脂肪酸实际上会增加机体器官衰竭的风险,比如橄榄油中所含的油酸,而且FDA推荐其能被人类安全食用;与此同时,胰腺中能破碎脂肪细胞中储存的脂质的酶类—PNLIP或许在专门储存脂质的细胞中并不丰富。

最后研究者Singh说道,本文研究或为开发治疗胰腺炎从而抑制机体器官衰竭的新型疗法提供了一定的思路,通过抑制PNLIP的功能,我们或许能够抑制严重胰腺炎的发生,同时避免延长患者的住院时间并挽救其生命。(生物谷Bioon.com)

原始出处:

Study links obesity with pancreatitis

A study by researchers at Mayo Clinic in Arizona published in the the Journal of Clinical Investigation has found that obesity is not only implicated in chronic diseases such as diabetes, but also in sudden-onset diseases such as pancreatitis.

"In our study, we were able to demonstrate that fat within the belly is rapidly degraded during acute pancreatitis, but not during diverticulitis, despite inflammation," says Vijay Singh, M.B.B.S., a Mayo Clinic gastroenterologist. Dr. Singh says while both diseases present with sudden belly pain and account for about 300,000 cases annually in the U.S., the rapid fat degradation that occurs in pancreatitis is triggered by a pancreatic enzyme called PNLIP. This enzyme can form fatty acids that cause vital body systems like circulation, kidney and lung functions to fail. Dr. Singh says this multisystem failure is much more common in acute pancreatitis than in diverticulitis......

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