Science:首次证实疟疾阿托伐醌耐药性不能通过蚊子传播
来源:生物谷 2016-04-19 21:23
在一项新的突破性研究中,研究人员发现对一种至关重要的抗疟疾药物产生的耐药性不能够通过蚊子进行传播。
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Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes
Christopher D. Goodman1,*,†, Josephine E. Siregar1,2,6,†, Vanessa Mollard1, Joel Vega-Rodríguez3, Din Syafruddin2,4, Hiroyuki Matsuoka5, Motomichi Matsuzaki6, Tomoko Toyama1, Angelika Sturm1, Anton Cozijnsen1, Marcelo Jacobs-Lorena3, Kiyoshi Kita6,7, Sangkot Marzuki2,‡, Geoffrey I. McFadden
Drug resistance compromises control of malaria. Here, we show that resistance to a commonly used antimalarial medication, atovaquone, is apparently unable to spread. Atovaquone pressure selects parasites with mutations in cytochrome b, a respiratory protein with low but essential activity in the mammalian blood phase of the parasite life cycle. Resistance mutations rescue parasites from the drug but later prove lethal in the mosquito phase, where parasites require full respiration. Unable to respire efficiently, resistant parasites fail to complete mosquito development, arresting their life cycle. Because cytochrome b is encoded by the maternally inherited parasite mitochondrion, even outcrossing with wild-type strains cannot facilitate spread of resistance. Lack of transmission suggests that resistance will be unable to spread in the field, greatly enhancing the utility of atovaquone in malaria control.
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