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J Dermatol:药物普萘洛尔或并不会影响婴儿的机体发育

来源:生物谷 2016-03-28 20:36

图片摘自:www.xinli001.com

2016年3月21日讯/生物谷BIOON/近日,来自上海交通大学的研究人员通过研究指出,对于婴儿性的毛细血管瘤而言,系统性普萘洛尔用药是安全的,而且并不会损伤婴儿的身体发育,该研究发表在了3月6日的国际杂志the Journal of Dermatology上。

研究人员Li Hu及其同事检测了系统性普萘洛尔(propranolol,心得安)疗法治疗婴儿性毛细血管瘤中婴儿机体的并发症情况,研究过程中每日给予婴儿2 mg的普萘洛尔;在疗法期间,研究者对婴儿的异常症状及生长参数进行记录,研究者共对76名患者进行了研究,并且对这些患者持续追踪直到其2岁。

文章中,研究者发现,药物普萘洛尔会引起一些最小的并发症,比如睡眠障碍、腹泻、空腹血糖降低、支气管多动症及高钾血症;在疗法过程中,4名患者(5.26%)的生长曲线下降了20多个百分点,在药物戒断一半后后曲线会恢复到正常,当疗法停止后,并没有一位患者出现体重过轻、消瘦或昏迷的症状。

最后研究者表示,系统性的普萘洛尔疗法被认为可以作为一种安全疗法来治疗婴儿性的毛细血管瘤,而且该疗法并不会影响到婴儿的机体发育。(生物谷Bioon.com)

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Effects of systemic propranolol treatment on physical growth of patients with infantile hemangiomas

Li Hu1,†, Bingrui Zhou2,†, Huizhen Huang1, Lei Chang1, Yajing Qiu1, Gang Ma1, Hui Chen1, Yunbo Jin1, Xiu Xu2, Xiaoxi Lin1 andWei Li1,

Abstract Propranolol has been widely used in the treatment of infantile hemangiomas since 2008. This study aimed to investigate complications of systemic propranolol therapy for infantile hemangiomas, especially its effect on infants' physical growth. In this study, propranolol was given at a dose of 2 mg/kg per day. Abnormal symptoms and growth parameters were recorded in detail during the therapy. Follow-up visits were arranged to continue at least through the age of 2 years. A total of 76 patients with complete growth parameters were enrolled into the study. Complications of propranolol were minor, and mainly included sleeping disorders, diarrhea, decrease in fasting glucose, bronchial hyperactivity and hyperkalemia. Four (5.26%) patients' growth curve dropped off more than 20 percentiles during therapy and half of them returned to normal after withdrawal of the medications. None of them suffered from underweight, wasting or stunning when medication was stopped. Systemic propranolol was proved to be a safe treatment for problematic infantile hemangiomas and did not affect the physical growth.

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