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Circulation Res:肠道细菌或可影响机体体重、脂肪及有益胆固醇水平

  1. 微生物
  2. 肠道菌群

来源:生物谷 2015-09-16 18:23

2015年9月16日讯/生物谷BIOON/-根据一项发表在《Circulation Research》杂志上的研究表示,为了你的心血管健康请及时检查你的肠道。生活在你肠道中的细菌可能会影响你的体重,脂肪和胆固醇水平,这些是帮助维持心脏

2015年9月16日讯/生物谷BIOON/-根据一项发表在《Circulation Research》杂志上的研究表示,为了你的心血管健康请及时检查你的肠道。生活在你肠道中的细菌可能会影响你的体重,脂肪和胆固醇水平,这些是帮助维持心脏健康的必要因素。

“我们的研究提供了新的证据,除了年龄、性别、体重指数和遗传因素外,肠道微生物的HDL血液水平和甘油三酯密切相关并且可以被作为血脂异常的一个新的危险因素。”Jingyuan Fu博士说,他是研究报告的主要作者,并且是荷兰格罗宁根大学医学中心遗传学副教授。

通过使用最先进的深度测序技术,研究人员在893个荷兰人中研究了肠道微生物和血脂水平之间的关系。他们发现了以下结果:

1.34个不同类型的细菌导致身体脂肪(BMI)和血脂差异,如甘油三酯和有益胆固醇称为高密度脂蛋白或HDL,大多数是新发现的联系。

2.肠道细菌导致了4.6%的身体脂肪差异,6%甘油三酯和4%的高密度脂蛋白差异。

3.令人惊讶的是,肠道细菌与有害胆固醇(低密度脂蛋白)或总胆固醇水平无关。

微生物和人类有一种共生关系。人体含有数以万亿计的微生物,是人体细胞数量的10倍。这些微生物帮助我们消化食物和提高我们的免疫系统。人类肠道中的菌群被认为是一种另外的器官,因为它对人体健康有非常重要的作用,研究人员说。

“不到30%的人类肠道细菌已在体外获得培养,我们对它们是什么以及它们在做什么知之甚少。用现有的深度测序技术,我们现在就能够识别它们。”Fu 说。

我们需要进一步的研究在更大的和多样化的人口中来测试他们的假设,研究人员相信这些发现可能会在某一天打开引起体重变化的改变肠道细菌类型的新疗法,脂肪和胆固醇水平有助于预防心脏病。

“我们也希望我们的发现使微生物学家继续研究这些细菌和其在脂质代谢中特定的功能作用。”Fu 说。(生物谷Bioon.com)

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生物谷推荐阅读:  For better cardiovascular health, check your gut. Bacteria living in your gut may impact your weight, fat and good cholesterol levels, factors necessary to help maintain a healthy heart, according to new research in Circulation Research, an American Heart Association journal.

"Our study provides new evidence that microbes in the gut are strongly linked to the blood level of HDL (good cholesterol) and triglycerides and may be added as a new risk factor for abnormal blood lipids, in addition to age, gender, BMI and genetics," said Jingyuan Fu, Ph.D., study lead author and associate professor of genetics at University Medical Center Groningen in the Netherlands.

Using state-of-the-art deep sequencing technology, researchers studied the association between gut microbes and blood lipid levels in 893 people in the Netherlands. They identified:

•34 different types of bacteria contributed to differences in body fat (BMI) and blood lipids such as triglycerides and the good cholesterol known as high-density lipoprotein or HDL. Most were new associations.
•Bacteria in the gut contributed to 4.6 percent of the difference in body fat, 6 percent in triglycerides and 4 percent in HDL.
•Surprisingly, gut bacteria had little relationship with bad cholesterol (low-density lipoproteins or LDL ) or total cholesterol levels.
Microbes and humans have a symbiotic relationship. The human body contains trillions of microorganisms, 10 times the number of human cells. These microbes help us to digest food and train our immune systems. The bacterial community in the human gut has been referred to as an extra organ because of its important role in an individuals' health, researchers said.

"As less than 30 percent of bacteria in the human gut have been cultured, we know very little about who they are and what they do. With state-of-art deep sequencing technology, we are now able to identify them," Fu said.

While additional studies are needed in a larger and diverse population to test their hypotheses, researchers believe these findings may someday open the door to new therapies to alter the gut bacteria types that contribute to body weight, fat and cholesterol levels to help aid in the prevention of heart disease.

"We also hope our findings inspire microbiologists to continue to research the function of these bacteria and their specific role in the regulation of lipid metabolism," Fu said.

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