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AJRCCM:HIV感染者与非感染者机体肺部的微生物菌群或具有相似性

  1. HIV
  2. 微生物菌群
  3. 感染者
  4. 相似
  5. 肺部
  6. 非感染者

来源:生物谷 2015-08-31 18:54

近日,一项发表在国际杂志the American Journal of Respiratory and Critical Care Medicine的研究论文中,来自科罗拉多大学的科学家表示,尽管HIV携带者和非携带者之间口腔微生物明显不同,但其肺部微生物菌群却表现出了一定的相似性。

2015年8月28日 讯 /生物谷BIOON/ --近日,一项发表在国际杂志the American Journal of Respiratory and Critical Care Medicine的研究论文中,来自科罗拉多大学的科学家表示,尽管HIV携带者和非携带者之间口腔微生物明显不同,但其肺部微生物菌群却表现出了一定的相似性。

研究者James M. Beck表示,我们对86名未感染HIV的个体、18名正在进行首次治疗的HIV感染者以及38名接受抗逆转录病毒治疗的个体进行研究,分析了参与者口腔冲洗液及支气管肺泡灌洗液(BALs)中16SrRNA的测序数据;研究者发现,所有参与者中的口腔冲洗液中的微生物菌群表现出了一定差异,这些微生物菌群主要包括链球菌、放线菌、罗氏菌以及奇异菌等;但研究者在参与者的支气管肺泡灌洗液中并没有发现微生物菌群的差异。

随后哦研究者还在未感染HIV的个体及接受抗逆转录病毒疗法的个体的口腔冲洗液及支气管肺泡灌洗液(BALs)中发现了相同的状况,而首次接受治疗的HIV感染个体机体中微生物菌群的模式或许和其它两组个体的并不相同,CD4细胞计数并不会影响口腔和支气管肺泡灌洗液中的微生物菌群。

最后研究者表示,发现HIV感染者和非感染者机体肺部微生物存在总体相似性我们非常惊讶,相对能够保持CD4细胞计数水平的HIV感染个体往往患下呼吸道感染的风险较高,这就揭示了患者或许机体局部的免疫功能处于受损的状态。(生物谷Bioon.com)

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Multi-center Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals

James M. Beck, Patrick D. Schloss, Arvind Venkataraman, Homer Twigg III, Kathleen A. Jablonski, Frederic D. Bushman, Thomas B. Campbell, Emily S. Charlson, Ronald G Collman, Kristina Crothers, Jeffrey L. Curtis, Kimberly L. Drews, Sonia C Flores, Andrew P Fontenot, Mary A. Foulkes, Ian Frank, Elodie Ghedin, Laurence Huang, Susan V Lynch, Alison Morris, Brent E Palmer, Thomas M. Schmidt, Erica Sodergren, George M. Weinstock, Vincent B. Young, and for the Lung HIV Microbiome Project

Rationale: Improved understanding of the lung microbiome in HIV-infected individuals could lead to better strategies for diagnosis, therapy, and prophylaxis of HIV-associated pneumonias. Differences in the oral and lung microbiomes in HIV-infected and HIV-uninfected individuals are not well defined. Whether highly active anti-retroviral therapy influences these microbiomes is unclear. Objectives: We determined whether oral and lung microbiomes differed in clinically healthy groups of HIV-infected and HIV-uninfected subjects. Methods: Participating sites in the Lung HIV Microbiome Project contributed bacterial 16S rRNA sequencing data from oral washes and bronchoalveolar lavages (BALs) obtained from HIV-uninfected individuals (n = 86), HIV-infected individuals who were treatment naïve (n = 18), and HIV-infected individuals receiving anti-retroviral therapy (n =38). Measurements and Main Results: Microbial populations differed in the oral washes among the subject groups (Streptococcus, Actinomyces, Rothia, and Atopobium), but there were no individual taxa that differed among the BALs. Comparison of oral washes and BALs demonstrated similar patterns from HIV-uninfected individuals and HIV-infected individuals receiving anti-retroviral therapy, with multiple taxa differing in abundance. The pattern observed from HIV-infected individuals who were treatment naïve differed from the other two groups, with differences limited to Veillonella, Rothia, and Granulicatella. CD4 cell counts did not influence the oral or BAL microbiome in these relatively healthy, HIV-infected subjects. Conclusions: The overall similarity of the microbiomes in participants with and without HIV infection was unexpected, since HIV-infected individuals with relatively preserved CD4 cell counts are at higher risk for lower respiratory tract infections, indicating impaired local immune function.

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