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PLoS One:MicroRNA标志物或是亚洲印度表型2型糖尿病患者的特点

来源:生物谷 2015-08-19 17:40

2015年8月19日讯/生物谷BIOON/--研究人员发现某些2型糖尿病患者“亚洲印度表型”的循环小分子核糖核酸(rna)生物标志物的作用特点——一种代谢性疾病被认为是印度韦达养生学疗法中的甜尿病。这项研究已经发表在《PLoS One》杂志上。

世界范围内多种组学技术正在调查并识别用于预防、诊断以及糖尿病方面治疗的生物标志物。近来,小分子核糖核酸被认为对非侵入性生物标记物有巨大潜力,用来预防、诊断和疾病预后,监测治疗和病人分层。这是因为循环小分子核糖核酸在人类中已被证明是稳定的、可重复的、在健康个体和病理生理学改变之间是一致的,使有临床实用价值的疾病生物标志物具有潜在价值。

“尽管还需要进一步研究和前瞻性研究,但是在改变的循环小分子核糖核酸之间,miR-128从未在先前的研究中被提及,这似乎是印度人中的一个“新方向”,研究人员Muthuswamy Balasubramanyam & Viswanathan Mohan说。“考虑到miR-128在早期记录中被作为一种认知障碍的生物标志物,并在2型糖尿病的病因中存在神经系统成分,miR-128可能与认知功能障碍有关,抑郁症与代谢疾病相关”Balasubramanyam说。

“当小分子核糖核酸测量的相关技术统一标准时,预计特定的小分子核糖核酸既能单独应用又能作为一种潜在的个性化医疗工具或精准医药。”Balasubramanyam补充道。(生物谷Bioon.com)

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Circulating MiRNAs of 'Asian Indian Phenotype' Identified in Subjects with Impaired Glucose Tolerance and Patients with Type 2 Diabetes.

Paramasivam Prabu, Sophie Rome, Chandrakumar Sathishkumar, Sankaramoorthy Aravind, Balakumar Mahalingam, Coimbatore Subramanian Shanthirani, Caroline Gastebois, Audrey Villard, Viswanathan Mohan, Muthuswamy Balasubramanyam

Several omics technologies are underway worldwide with an aim to unravel the pathophysiology of a complex phenotype such as type 2 diabetes mellitus (T2DM). While recent studies imply a clinically relevant and potential biomarker role of circulatory miRNAs in the etiology of T2DM, there is lack of data on this aspect in Indians—an ethnic population characterized to represent ‘Asian Indian phenotype’ known to be more prone to develop T2DM and cardiovascular disease than Europeans. We performed global serum miRNA profiling and the validation of candidate miRNAs by qRT-PCR in a cohort of subjects comprised of normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and patients with T2DM. Our study revealed 4 differentially expressed miRNAs (miR-128, miR-130b-3p, miR-374a-5p, miR-423-5p) in subjects with IGT and T2DM patients compared to control subjects. They were positively or negatively correlated to cholesterol levels, HbA1C, HOMA-IR and fasting insulin. Interestingly, circulating level of miR-128 and miR-130b-3p were also altered in serum of diet-induced diabetic mice compared to control animals. Among the altered circulating miRNAs, miR-128 had never been described in previous studies/populations and appeared to be a ‘New Lead’ in Indians. It was positively correlated with cholesterol both in prediabetic subjects and in diet-induced diabetic mice, suggesting that its increased level might be associated with the development of dyslipedemia associated with T2DM. Our findings imply directionality towards biomarker potential of miRNAs in the prevention/diagnosis/treatment outcomes of diabetes.

相关会议:2015生物标志物研讨会

会议官网:http://www.bioon.com/z/2015biomarker/

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