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AJCN:维生素B12或并不能改善老年个体的认知功能

来源:生物谷 2015-07-03 14:05

2015年7月3日 讯 /生物谷BIOON/ --近日,一项刊登于国际杂志the American Journal of Clinical Nutrition上的研究论文中,来自伦敦卫生和热带医学院的研究人员通过研究表示,维生素B12补充剂或许对机体中度缺乏B12的老年个体的认知和神经功能并无任何益处。

在英国75岁以上的老年人中,大约六分之一的个体都存在机体维生素B12缺乏的情况,当维生素B12缺乏严重时就会引发个体神经系统出现明显的问题,比如肌无力、行走困难等疾病;维生素B12在每天的食物中都存在,比如鱼类、肉类、乳制品和家禽等。目前有明确的证据表明,患有严重维生素B12缺乏的个体会在疗法中明显获益,然而却并没有明确的证据表明维生素B12疗法对B12中度缺乏个体会带来帮助。

此前研究表明维生素B12中度缺乏的个体的神经和记忆功能较差,而每日维生素B12补充剂对于纠正其中度缺乏对机体神经系统功能的效应此前并不清楚。这项研究中,研究者对201名年龄在75岁以上的老年个体进行研究,这些个体都为维生素B12中度缺乏,而且他们并不患贫血,这些个体每日服用维生素B12药片或安慰剂,服用时间为1年;在研究结束后研究者对参与者进行临床检测来评估其机体神经系统的功能,包括肌肉力量测定、协调性、运动型、记忆认知能力及心理健康等。

结果研究者表示,那些服用维生素B12的个体和服用安慰剂的个体在神经系统和认知功能的改善上并无差异;研究者Alan Dangour说道,这项研究首次研究阐明了维生素B12补充剂对B12中度缺失的老年个体机体的神经功能和认知功能的影响;目前有很多个体都非常有规律地服用维生素B12,他们认为这会增强其机体的神经认知功能,但本文研究发现这好像并没有任何作用。

研究者建议个体应当通过多样性健康的饮食方式以及健康锻炼来保持其机体的认知功能的健康;虽然本研究中涉及的研究对象数量较少,但研究者表示,这个数量已经足以检测维生素B12对机体认知功能的影响;下一步研究者还将进行更多深入的研究来解析为何维生素B12补充剂对改善老年个体认知功能并没有作用。(生物谷Bioon.com)

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Effects of vitamin B-12 supplementation on neurologic and cognitive function in older people: a randomized controlled trial1,2.

Alan D Dangour3,*, Elizabeth Allen3, Robert Clarke4, Diana Elbourne3, Astrid E Fletcher3, Louise Letley5, Marcus Richards6, Ken Whyte3, Ricardo Uauy3, and Kerry Mills7

Background: Moderate vitamin B-12 deficiency is relatively common in older people. However, there is little robust evidence on the effect of vitamin B-12 supplementation on neurologic and cognitive outcomes in later life. Objective: We investigated whether vitamin B-12 supplementation benefits neurologic and cognitive function in moderately vitamin B-12–deficient older people. Design: We conducted a double-blind, randomized, placebo-controlled trial in 7 general practices in South East England, United Kingdom. Study participants were aged ≥75 y and had moderate vitamin B-12 deficiency (serum vitamin B-12 concentrations: 107–210 pmol/L) in the absence of anemia and received 1 mg crystalline vitamin B-12 or a matching placebo as a daily oral tablet for 12 mo. Peripheral motor and sensory nerve conduction, central motor conduction, a clinical neurologic examination, and cognitive function were assessed before and after treatment. Results: A total of 201 participants were enrolled in the trial, and 191 subjects provided outcome data. Compared with baseline, allocation to vitamin B-12 was associated with a 177% increase in serum concentration of vitamin B-12 (641 compared with 231 pmol/L), a 331% increase in serum holotranscobalamin (240 compared with 56 pmol/L), and 17% lower serum homocysteine (14.2 compared with 17.1 μmol/L). In intention-to-treat analysis of covariance models, with adjustment for baseline neurologic function, there was no evidence of an effect of supplementation on the primary outcome of the posterior tibial compound muscle action potential amplitude at 12 mo (mean difference: −0.2 mV; 95% CI: –0.8, 0.3 mV). There was also no evidence of an effect on any secondary peripheral nerve or central motor function outcome, or on cognitive function or clinical examination. Conclusion: Results of the trial do not support the hypothesis that the correction of moderate vitamin B-12 deficiency, in the absence of anemia and of neurologic and cognitive signs or symptoms, has beneficial effects on neurologic or cognitive function in later life. This trial was registered at www.isrctn.com as ISRCTN54195799.

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