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CAACJC:二氧化硅暴露或增加个体患肺癌风险

来源:生物谷 2014-01-02 00:13

2014年1月2日 讯 /生物谷BIOON/ --近日,刊登在国际杂志CA:A Cancer Journal for Clinicians上的一篇研究论文中,来自艾默里大学的研究者通过研究在文中揭示了二氧化硅对人体的健康效应,研究者倡议减少个体暴露于二氧化硅的机会,而且鼓励个体增加进行早期矽肺病和肺癌的检查。

几个世纪以来,二氧化硅被认为可以引发肺部疾病(矽肺病),而且相关的研究证据越来越多。这项研究中研究者指出了三点重要的改变,为阻断因二氧化硅暴露引发的疾病和死亡奠定了基础。首先很多研究结果可以用以评估疾病的风险,而且最新研究也表明未患矽肺病以及不抽烟的工人,暴露于二氧化硅可以明显增加其患肺部疾病甚至死亡的风险。

第二点中研究者表示,很多新规已经出台降低了大约220万工人暴露于二氧化硅的风险;第三,低剂量的CT扫描技术可以帮助个体来进行早期肺癌及疾病的诊断。大约有32万工人在日常的工业施工中,比如砌砖、陶器制作过程中都会暴露在二氧化硅中,当前最有效的控制二氧化硅暴露的方法包括控制粉尘扩散等措施。

研究者Steenland博士说道,当前很多措施都会从根本上降低矽肺病引发的死亡,但是新发患者也会马上出现,而且肺癌不仅仅和二氧化硅暴露相关,而且和吸烟、石棉暴露也存在一定关联,但是很多研究已经确定了二氧化硅暴露可以明显增加个体肺癌的风险,因此减少暴露时间以及进行早期的诊断对于控制个体疾病的发展最为有效。(生物谷Bioon.com)

Silica: A lung carcinogen.

Steenland K, Ward E.

Silica has been known to cause silicosis for centuries, and evidence that silica causes lung cancer has accumulated over the last several decades. This article highlights 3 important developments in understanding the health effects of silica and preventing illness and death from silica exposure at work. First, recent epidemiologic studies have provided new information about silica and lung cancer. This includes detailed exposure-response data, thereby enabling the quantitative risk assessment needed for regulation. New studies have also shown that excess lung mortality occurs in silica-exposed workers who do not have silicosis and who do not smoke. Second, the US Occupational Safety and Health Administration has recently proposed a new rule lowering the permissible occupational limit for silica. There are approximately 2 million US workers currently exposed to silica. Risk assessments estimate that lowering occupational exposure limits from the current to the proposed standard will reduce silicosis and lung cancer mortality to approximately one-half of the rates predicted under the current standard. Third, low-dose computed tomography scanning has now been proven to be an effective screening method for lung cancer. For clinicians, asking about occupational history to determine if silica exposure has occurred is recommended. If such exposure has occurred, extra attention might be given to the early detection of silicosis and lung cancer, as well as extra emphasis on quitting smoking.

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