新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » Nature报道 » Nature:SHANK3基因的过度表达

Nature:SHANK3基因的过度表达

来源:Nature中文网 2013-11-07 10:49

SHANK3(编码SHANK3突触支架蛋白的基因)发生的突变与自闭症、智残和精神分裂症有关,但SHANK3过度表达的效应却不大清楚。

现在,Huda Zoghbi及同事发现,过度表达Shank3的小鼠会表现出类似狂躁的行为以及癫痫发作和神经活动的激发/抑制平衡发生改变等。与在小鼠身上的这些发现相一致的是,他们识别出了在22号染色体上携带含SHANK3区域的一个基因复本的两个多动症患者。

这些发现支持以下假设:任何一个方向上(过度表达和表达不足)的不正确基因剂量都可能是有害的。作者提出,这项研究中所用的小鼠为了解某些形式的躁郁症的药物遗传机理提供了一个模型。(生物谷Bioon.com)

生物谷推荐的英文摘要

Nature       doi:10.1038/nature12630

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties

Kihoon Han,J. Lloyd Holder Jr,Christian P. Schaaf,Hui Lu,Hongmei Chen,Hyojin Kang,Jianrong Tang,Zhenyu Wu,Shuang Hao,Sau Wai Cheung,Peng Yu,Hao Sun,Amy M. Breman,Ankita Patel,Hui-Chen Lu& Huda Y. Zoghbi

Mutations in SHANK3 and large duplications of the region spanning SHANK3 both cause a spectrum of neuropsychiatric disorders, indicating that proper SHANK3 dosage is critical for normal brain function. However, SHANK3 overexpression per se has not been established as a cause of human disorders because 22q13 duplications involve several genes. Here we report that Shank3 transgenic mice modelling a human SHANK3 duplication exhibit manic-like behaviour and seizures consistent with synaptic excitatory/inhibitory imbalance. We also identified two patients with hyperkinetic disorders carrying the smallest SHANK3-spanning duplications reported so far. These findings indicate that SHANK3 overexpression causes a hyperkinetic neuropsychiatric disorder. To probe the mechanism underlying the phenotype, we generated a Shank3 in vivo interactome and found that Shank3 directly interacts with the Arp2/3 complex to increase F-actin levels in Shank3 transgenic mice. The mood-stabilizing drug valproate, but not lithium, rescues the manic-like behaviour of Shank3 transgenic mice raising the possibility that this hyperkinetic disorder has a unique pharmacogenetic profile.

 

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!


相关标签

最新会议 培训班 期刊库