打开APP

肺结核新标记物为新疗法的开发点亮希望

  1. 生物标记物
  2. 肺结核

来源:生物谷 2013-08-21 10:33

2013年8月20日讯 /生物谷BIOON/ --根据英国南开普敦大学研究人员的一项研究显示,肺结核病人肺部被破坏后产生的一些蛋白质降解产物有希望成为新的肺结核生物标记物。研究人员在介绍这项早期研究时表示这种降解物在过去从未被发现过。 全球每年有150万人死于肺结核,其中大部分生活在发展中国家。由于诊断和治疗肺结核的方法已经有数十年没有改变过,肺结核病人中已经出现了很多抗药性菌株。

2013年8月20日讯 /生物谷BIOON/ --根据英国南开普敦大学研究人员的一项研究显示,肺结核病人肺部被破坏后产生的一些蛋白质降解产物有希望成为新的肺结核生物标记物。研究人员在介绍这项早期研究时表示这种降解物在过去从未被发现过。

全球每年有150万人死于肺结核,其中大部分生活在发展中国家。由于诊断和治疗肺结核的方法已经有数十年没有改变过,肺结核病人中已经出现了很多抗药性菌株。因此开发新的疗法和诊断方式已经迫在眉睫。(生物谷Bioon.com)

详细英文报道:

Tuberculosis' destruction of the lungs could ultimately open up new avenues of treatment. That's because fragments freed by the breakdown of the lung's key proteins in TB patients may prove to be promising new biomarkers for the disease in a number of ways, U.K. and South African researchers have concluded in a new study.

Crucially, they see the newly identified substances as opening the door to both better diagnostics and treatments for the first time in decades.

"These lung breakdown products have never been identified in TB before and have the potential to be used as new markers to identify patients with TB and monitor the effect of new treatments," lead study author Paul Elkington at the University of Southampton said in a statement.

It's an early finding, of course. And more research is needed to validate the initial results. But the study is promising enough that the research team is moving ahead with a study of all fragments freed by lung decline in TB patients. They'll use that data to develop diagnostic tests a patient can use at bedside.

The gist: The sputum of patients with TB contains fragments released by the breakdown of the lungs' key proteins, collagen and elastin, as TB damage escalates. Additionally, they found the PIIINP collagen fragment at higher-than-normal blood levels in TB patient blood samples.

As Elkington notes, there's a huge need for both diagnostics and treatments, with 1.5 million people globally dying from TB each year, largely in the developing world. These patients are hammered by the increase of drug-resistant infections, Elkington said. And they continue to rely on first-line TB tests and drugs that haven't changed for three decades. And so new diagnostic tests and treatments are crucial to combat TB as it proliferates.

Beyond the University of Southampton, colleagues at Imperial College London, the University of Cape Town in South Africa and the KwaZulu-Natal Research Institute for Tuberculosis and HIV in Durban also participated, along with other colleagues. The Journal of Infectious Diseases published details of their work.

 

版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站所有。非经授权,任何媒体、网站或个人不得转载,否则将追究法律责任。取得书面授权转载时,须注明“来源:生物谷”。其它来源的文章系转载文章,本网所有转载文章系出于传递更多信息之目的,转载内容不代表本站立场。不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。

87%用户都在用生物谷APP 随时阅读、评论、分享交流 请扫描二维码下载->