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Cell Metab:李校堃团队在治疗糖尿病候选药物FGF21研究上取得成果

  1. 成纤维细胞
  2. 李校堃
  3. 糖尿病

来源:生物谷 2013-05-22 14:38

上海 2013年5月22日电 /生物谷BIOON/ --5月7日,《Cell Metabolism》杂志全文发表了温州医学院李校堃教授课题组的最新研究成果:"Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice"(Cell Metaboli

上海 2013年5月22日电 /生物谷BIOON/ --5月7日,《Cell Metabolism》杂志全文发表了温州医学院李校堃教授课题组的最新研究成果:"Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice"(Cell Metabolism 17, 779-789, may 7, 2013)。该研究揭示了脂联素是成纤维细胞生长因子-21(以下简称FGF21)参与糖脂代谢调控以及胰岛素增敏效应的下游作用因子。该研究结果为进一步推进FGF21作为一个新型的糖尿病治疗候选药物研究提供了理论依据。

上世纪90年代初期,李校堃教授开始研究成纤维细胞生长因子,早期主要集中在aFGF和bFGF的药物研发方面。经过10多年的努力,先后开发出重组人酸性成纤维细胞生长因子(rhbFGF)、重组人碱性成纤维细胞生长因子和重组牛碱性成纤维细胞生长因子(rbbFGF)等3个国家生物制品一类新药,在创伤修复领域得到了广泛应用,产生了良好的社会和经济效益。(生物谷Bioon.com)

10.1016/j.cmet.2013.04.005

Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice

Zhuofeng Lin, Haishan Tian, Karen S.L. Lam, Shaoqiang Lin, Ruby C.L. Hoo, Morichika Konishi, Nobuyuki Itoh, Yu Wang3, Stefan R. Bornstein, Aimin Xu, ,   and Xiaokun Li

Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on regulating glucose and lipid homeostasis and insulin sensitivity. However, the mechanisms underlying the metabolic actions of FGF21 remain unknown. Here we show that the insulin-sensitizing adipokine adiponectin is a downstream effector of FGF21. Treatments with FGF21 enhanced both expression and secretion of adiponectin in adipocytes, thereby increasing serum levels of adiponectin in mice. Adiponectin knockout mice were refractory to several therapeutic benefits of FGF21, including alleviation of obesity-associated hyperglycemia, hypertriglyceridemia, insulin resistance, and hepatic steatosis. Furthermore, the effects of FGF21 on attenuation of obesity-induced impairment in insulin signaling in liver and skeletal muscle were abrogated in adiponectin knockout mice, whereas FGF21-mediated activation of ERK1/ERK2 in adipose tissues remained unaffected. Therefore, adiponectin couples FGF21 actions in local adipocytes to liver and skeletal muscle, thereby mediating the systemic effects of FGF21 on energy metabolism and insulin sensitivity.

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