打开APP

NRR:黄岑苷能促进慢性应激大鼠海马区的神经发生?

  1. 海马区
  2. 神经发生
  3. 糖皮质激素
  4. 黄岑苷

来源:EurekAlert!中文 2013-06-19 20:19

一项关于“Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats”的研究,通过连续14 d皮下注射40 mg/kg糖皮质激素建立成年SD大鼠慢性应激模型,与此同时灌胃50 mg/kg的黄岑苷,观察其对慢性应激大鼠神经发生的影响。

一项关于“Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats”的研究,通过连续14 d皮下注射40 mg/kg糖皮质激素建立成年SD大鼠慢性应激模型,与此同时灌胃50 mg/kg的黄岑苷,观察其对慢性应激大鼠神经发生的影响。

结果显示皮下注射糖皮质激素可显著降低海马中doublecortin阳性神经元数目,且糖皮质激素导致的海马神经元减少以II型doublecortin阳性神经元为主,而I型doublecortin阳性神经元不受影响。

 免疫组织化学染色可见黄岑苷干预后慢性应激模型大鼠海马齿状回doublecortin阳性表达

黄岑苷可显著提高糖皮质激素诱导的慢性应激模型大鼠海马中I型和II型doublecortin阳性神经元数目。此外,黄岑苷还能逆转糖皮质激素注射可引起doublecortin阳性神经元树突形态发生萎缩。

作者认为,黄岑苷具有促进成体动物海马神经发生的作用,可能使其在改善认知功能和情绪调节中有潜在的治疗作用和临床应用前景。

该结果发表在《中国神经再生研究(英文版)》(Neural Regeneration Research)杂志2013年2月第6期。(生物谷Bioon.com)

Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats

Xinghua Jiang, Junmei Xu, Dingquan Zou, Lin Yang, Yaping Wang.

Chronic stress models, established in adult Sprague-Dawley rats through a 14-day subcutaneous injection of 40 mg/kg corticosterone, once per day, were given a daily oral feeding of 50 mg/kg baicalin. The study was an attempt to observe the effect of baicalin on neurogenesis in chronically stressed rats. Results showed that subcutaneous injection of corticosterone significantly decreased the total number of doublecortin-positive neurons in the hippocampus. The reduced cell number caused by corticosterone was mainly due to the decrease of class II doublecortin-positive neurons, but the class I doublecortin-positive neurons were unaffected. Baicalin treatment increased the number of both class I and class II doublecortin-positive neurons. In addition, doublecortin-positive neurons showed less complexity in dendritic morphology after corticosterone injection, and this change was totally reversed by baicalin treatment. These findings suggest that baicalin exhibits a beneficial effect on adult neurogenesis.

版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站所有。非经授权,任何媒体、网站或个人不得转载,否则将追究法律责任。取得书面授权转载时,须注明“来源:生物谷”。其它来源的文章系转载文章,本网所有转载文章系出于传递更多信息之目的,转载内容不代表本站立场。不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。

87%用户都在用生物谷APP 随时阅读、评论、分享交流 请扫描二维码下载->