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JEM:肠道粘液中一种粘液素有助防治肠道寄生虫

来源:新华网 2011-05-10 10:33

英国研究人员日前报告说,他们发现肠道粘液中如果存在一种粘液素,则肠道组织排除寄生虫的能力更强。

这一发现不仅能够解释为什么有些人天然对肠道寄生虫有更强免疫力,还有助于研发防治肠道寄生虫的新方法。

英国曼彻斯特大学等机构研究人员报告说,他们观察了不同实验鼠感染肠道寄生虫鼠鞭虫后的情况,发现那些天然排虫能力更强的实验鼠的肠道粘液中存在一种名为“Muc5ac”的粘液素。粘液素是一种蛋白质,是肠道等器官表面粘液的成分之一。

据介绍,这种粘液素通常存在于肺部,很少出现在肠道中。但如果它存在于肠道中,肠道粘液就会变得对寄生虫有害,从而起到帮助排虫的效果。实验显示,那些由于基因缺陷而天然不能生成这种粘液素的实验鼠,在感染了寄生虫之后,即使机体可能会出现更强的免疫反应,也难以排除寄生虫,从而导致一些长期持续的疾病症状。

研究人员苏梅拉·哈斯南说,这是首次发现一种粘液素有助防治肠道寄生虫。人类肠道也会感染与鼠鞭虫类似的鞭虫以及钩虫等寄生虫,它们引起的疾病可能影响超过10亿人。本次研究成果可帮助区分对肠道寄生虫有不同免疫力的人群,从而进行有针对性的防治,还可能在此基础上研发出防治肠道寄生虫的新方法。

研究报告发表在新一期美国《实验医学期刊》上。(生物谷Bioon.com)

生物谷推荐原文出处:

JEM  doi: 10.1084/jem.20102057

Muc5ac: a critical component mediating the rejection of enteric nematodes

Sumaira Z. Hasnain1,2, Christopher M. Evans3, Michelle Roy3, Amanda L. Gallagher2, Kristen N. Kindrachuk4, Luke Barron4, Burton F. Dickey3, Mark S. Wilson5, Thomas A. Wynn4, Richard K. Grencis2, and David J. Thornton1

Abstract

De novo expression of Muc5ac, a mucin not normally expressed in the intestinal tract, is induced in the cecum of mice resistant to Trichuris muris infection. In this study, we investigated the role of Muc5ac, which is detected shortly before worm expulsion and is associated with the production of interleukin-13 (IL-13), in resistance to this nematode. Muc5ac-deficient mice were incapable of expelling T. muris from the intestine and harbored long-term chronic infections, despite developing strong TH2 responses. Muc5ac-deficient mice had elevated levels of IL-13 and, surprisingly, an increase in the TH1 cytokine IFN-γ. Because TH1 inflammation is thought to favor chronic nematode infection, IFN-γ was neutralized in vivo, resulting in an even stronger TH2-type immune response. Nevertheless, despite a more robust TH2 effector response, the Muc5ac-deficient mice remained highly susceptible to chronic T. muris infection. Importantly, human MUC5AC had a direct detrimental effect on nematode vitality. Moreover, the absence of Muc5ac caused a significant delay in the expulsion of two other gut-dwelling nematodes (Trichinella spiralis and Nippostrongylus brasiliensis). Thus, for the first time, we identify a single mucin, Muc5ac, as a direct and critical mediator of resistance during intestinal nematode infection.

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