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Science:血小板会激化类风湿性关节炎

来源:EurekAlert! 2010-01-29 09:12

专题:Science报道

据1月29日的《科学》杂志报道说,血小板所脱落的极为细小的颗粒可能进入到关节液中,并会加剧与类风湿关节炎有关的炎症。 文章的作者还发现了一种叫做GPVI的蛋白,该蛋白会刺激这些粒子的产生。这些现象提示,阻断该蛋白可能是治疗这类关节炎的一种新的途径。 尽管血小板最出名的是它们在血凝块形成中所起的关键作用,但它在炎症过程中也扮演着一种角色的证据也在不断地增加。 来自血小板的微小颗粒是血小板被激活时所释放出的小囊泡,这些小囊泡可将生物分子运送到身体的各个部位。

Eric Boilard及其同僚如今发现,这些颗粒可能会促进造成类风湿性关节炎的炎症过程。类风湿性关节炎是一种自身免疫性疾病。 他们发现,这种颗粒存在于不同类型的炎症性关节炎患者的关节液中,但它们在骨关节炎患者的滑液中则阙如。骨关节炎没有牵涉到与炎症性关节炎相同的那种炎性过程。 在一种炎症性关节炎的小鼠模型中将血小板耗尽也能够抑制该疾病的进展。 一篇相关的Perspective讨论了这些发现,其中包括这些微小颗粒是如何进入到关节液中的问题。(生物谷Bioon.com)

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Science 29 January 2010: DOI: 10.1126/science.1181928

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

Eric Boilard,1 Peter A. Nigrovic,1,2 Katherine Larabee,1 Gerald F. M. Watts,1 Jonathan S. Coblyn,1 Michael E. Weinblatt,1 Elena M. Massarotti,1 Eileen Remold-O’Donnell,3 Richard W. Farndale,4 Jerry Ware,5 David M. Lee1,*

In addition to their pivotal role in thrombosis and wound repair, platelets participate in inflammatory responses. We investigated the role of platelets in the autoimmune disease rheumatoid arthritis. We identified platelet microparticles—submicrometer vesicles elaborated by activated platelets—in joint fluid from patients with rheumatoid arthritis and other forms of inflammatory arthritis, but not in joint fluid from patients with osteoarthritis. Platelet microparticles were proinflammatory, eliciting cytokine responses from synovial fibroblasts via interleukin-1. Consistent with these findings, depletion of platelets attenuated murine inflammatory arthritis. Using both pharmacologic and genetic approaches, we identified the collagen receptor glycoprotein VI as a key trigger for platelet microparticle generation in arthritis pathophysiology. Thus, these findings demonstrate a previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases.

1 Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
2 Division of Immunology, Children’s Hospital Boston, Boston, MA 02115, USA.
3 Immune Disease Institute, Harvard Medical School, Boston MA 02115, USA.
4 University of Cambridge, Department of Biochemistry, Downing Site, Cambridge CB2 1QW, UK.
5 University of Arkansas for Medical Sciences, Little Rock, AR 72205–7199, USA.

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