AJCN:机体中硒的水平或影响个体患癌的风险
来源:生物谷 2016-09-05 08:39
作为微量营养元素,硒构成了我们饮食中的必要部分,近日,来自国际癌症研究机构(IARC)等处的研究人员通过研究发现,血液中较高的硒水平或许和个体患肝癌风险降低直接相关,除了其它风险因素以外,研究者还检测了血液中的硒水平影响机体患其它癌症风险的机制,相关研究刊登于国际杂志the American Journal of Clinical Nutrition上。
图片摘自:www.medindia.net
2016年9月1日 讯 /生物谷BIOON/ --作为微量营养元素,硒构成了我们饮食中的必要部分,近日,来自国际癌症研究机构(IARC)等处的研究人员通过研究发现,血液中较高的硒水平或许和个体患肝癌风险降低直接相关,除了其它风险因素以外,研究者还检测了血液中的硒水平影响机体患其它癌症风险的机制,相关研究刊登于国际杂志the American Journal of Clinical Nutrition上。
许多食物中都含有硒(Se),比如鱼类、贝类、肉类、牛奶和鸡蛋等,而且一些南美坚果类,比如巴西坚果中也富含硒;相比世界上其它区域而言,欧洲土壤中硒的富集水平相对较低,在一般人群中往往存在不同水平的硒缺乏现象,而且德国的家畜在喂养过程中也需要进行额外的硒补充剂。
在欧洲,富含硒的饮食以及足够的硒补充剂都并不会引发副作用,相反研究者认为硒的缺失或许是诱发一系列疾病的主要风险因子,研究者Lutz Schomburg教授表示,我们通过研究发现,硒的缺乏是引发肝癌的主要风险因子,此外,据我们的研究数据显示,处于硒低水平状态的三分之一的人口患肝细胞癌的风险都会增加5-10倍。
在一项回顾性研究中,研究者对477,000名参与者进行了研究,从中选择了在10年随访过程中患上肝细胞癌的参与者;同时研究者对健康参与者的血液样本进行了收集并进行了相关分析来确定其血液中硒的水平;这项研究并没有揭示,硒补充剂对于抵御肝癌有着直接的保护作用,然而研究者却发现平衡饮食非常关键,因为硒组成了饮食的主要部分。此前的研究结果也发现了类似的关联,即个体机体中的硒水平和其患结肠癌以及自身免疫性甲状腺病的风险之间的关联。(生物谷Bioon.com)
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Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort1,2
David J Hughes3,46,*, Talita Duarte-Salles4,5,46, Sandra Hybsier6, Antonia Trichopoulou7,8, Magdalena Stepien4, Krasimira Aleksandrova9, Kim Overvad10, Anne Tjønneland11, Anja Olsen11, Aurélie Affret12–14, Guy Fagherazzi12–14, Marie-Christine Boutron-Ruault12–14, Verena Katzke15, Rudolf Kaaks15, Heiner Boeing9, Christina Bamia7,8, Pagona Lagiou7,8,16, Eleni Peppa7, Domenico Palli17, Vittorio Krogh18, Salvatore Panico19, Rosario Tumino20, Carlotta Sacerdote21, Hendrik Bastiaan Bueno-de-Mesquita22–24,27, Petra H Peeters25,26, Dagrun Engeset28, Elisabete Weiderpass29–32, Cristina Lasheras33, Antonio Agudo34, Maria-José Sánchez35,34, Carmen Navarro36–38, Eva Ardanaz36,39,40, Miren Dorronsoro41, Oskar Hemmingsson42, Nicholas J Wareham43, Kay-Tee Khaw44, Kathryn E Bradbury45, Amanda J Cross27, Marc Gunter27, Elio Riboli27, Isabelle Romieu4, Lutz Schomburg6,47, and Mazda Jenab4,47
Background: Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract. Objective: We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Design: We assessed prediagnostic selenium status by measuring serum concentrations of selenium and selenoprotein P (SePP; the major circulating selenium transfer protein) and examined the association with hepatocellular carcinoma (HCC; n = 121), gallbladder and biliary tract cancers (GBTCs; n = 100), and intrahepatic bile duct cancer (IHBC; n = 40) risk in a nested case-control design within the EPIC study. Selenium was measured by total reflection X-ray fluorescence, and SePP was determined by a colorimetric sandwich ELISA. Multivariable ORs and 95% CIs were calculated by using conditional logistic regression. Results: HCC and GBTC cases, but not IHBC cases, showed significantly lower circulating selenium and SePP concentrations than their matched controls. Higher circulating selenium was associated with a significantly lower HCC risk (OR per 20-μg/L increase: 0.41; 95% CI: 0.23, 0.72) but not with the risk of GBTC or IHBC. Similarly, higher SePP concentrations were associated with lowered HCC risk only in both the categorical and continuous analyses (HCC: P-trend ≤ 0.0001; OR per 1.5-mg/L increase: 0.37; 95% CI: 0.21, 0.63). Conclusion: These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.
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