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Psych Med:惊人发现!精神分裂症患者的大脑或有能力“自愈”

来源:生物谷 2016-06-02 23:12

图片来源:www.sciencealert.com

2016年6月2日 讯 /生物谷BIOON/ --近日,刊登于国际杂志Psychology Medicine上的一项研究报告中,来自加拿大罗森健康研究中心(Lawson Health Research Institute)的研究人员通过研究发现,受精神分裂症影响的大脑或会进行重组并且抵御疾病发展,该研究或可帮助科学家们理解精神分裂症发生的机制,同时为开发新型疗法治疗相关疾病提供帮助。

目前在全球范围内有超过2100万精神分裂症患者,研究者发现,当提及大脑灰质容量时,随着时间过去这种大脑修复效应实际上会使得精神分裂症患者的大脑,慢慢转变成为没有患病的状态,而这就或许就可以帮助开发新型治疗精神分裂症的新型方法。文章中,研究者对98名精神分裂症患者及83名非精神分裂症患者进行研究,利用MRI扫描后发现,精神分裂症患者大脑的特殊部位的组织发生了少量增加,同时其它区域的灰质含量却减少了。

本文研究结果或与此前建立的关于精神分裂症的理论相违背,此前科学家们认为精神分裂症在发病初期会永久性地损伤大脑组织,而且这些损伤不会被逆转。研究人员Lena Palaniyappan说道,我们的研究结果表明,尽管精神分裂症会带来严重的组织损伤,但精神分裂症患者的大脑却会不断尝试着自我组装,而且尽可能地去恢复或抑制损伤的进展。

研究者利用了协方差分析的方法更加全面地研究了精神分裂症患者的大脑,他们发现,随着时间延续,精神分裂症患者的大脑会慢慢变得“正常”; Paul Links说道,目前我们并不清楚引发精神分裂症的具体作用机制,很多药物和疗法都可以降低患者的疾病效应,从而帮助患者正常的生活,然而基于当前的最新研究结果,我们就可以对精神分裂症发病的分子机制进行更加深入的研究。(生物谷Bioon.com)

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Dynamic cerebral reorganization in the pathophysiology of schizophrenia: a MRI-derived cortical thickness study.

Guo S1, Palaniyappan L2, Liddle PF2, Feng J3.

BACKGROUND: A structural neuroanatomical change indicating a reduction in brain tissue is a notable feature of schizophrenia. Several pathophysiological processes such as aberrant cortical maturation, progressive tissue loss and compensatory tissue increase could contribute to the structural changes seen in schizophrenia. METHOD: We studied cortical thickness using surface-based morphometry in 98 clinically stable patients with schizophrenia and 83 controls. Using a pattern classification approach, we studied whether the features that discriminate patients from controls vary across the different stages of the illness. Using a covariance analysis, we also investigated if concurrent increases accompany decreases in cortical thickness. RESULTS: Very high levels of accuracy (96.3%), specificity (98.8%) and sensitivity (88%) were noted when classifying patients with <2 years of illness from controls. Within the patient group, reduced thickness was consistently accompanied by increased thickness in distributed brain regions. A pattern of cortical amelioration or normalization (i.e. reduced deviation from controls) was noted with increasing illness duration. While temporo-limbic and fronto-parietal regions showed reduced thickness, the occipital cortex showed increased thickness, especially in those with a long-standing illness. CONCLUSION: A compensatory remodelling process might contribute to the cortical thickness variations in different stages of schizophrenia. Subtle cerebral reorganization reflecting the inherent plasticity of brain may occur concomitantly with processes contributing to tissue reduction in adult patients with schizophrenia.

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