来源：生物谷 2016-05-12 00:09
图片摘自：www.popsci.com
2016年5月12日 讯 /生物谷BIOON/ --近日，发表于国际杂志CANCER上的一项研究论文中，来自国外的研究人员通过研究发现，随着机体慢慢老化，癌症或许会对个体的身心健康带来负面影响；文章中研究者发现，癌症可以增加个体超出正常机体老化范围的特定健康问题，其中一部分原因或许是由于和个体癌症诊断及治疗过程相关的体力活动水平的下降及压力的增加。
随着人口老龄化的增加，对于临床医生们而言越来越重视研究癌症对老年个体的特殊影响，文章中研究人员对和美国的联邦医疗保险(Medicare)调查相关的癌症登记数据进行了分析，这项分析涵盖了921名患乳腺癌、结直肠癌、肺癌及前列腺癌保险受益患者的相关数据，这些患者在1998年和2001年完成了初期调查，在接下来两年里研究者对这些研究者进行追踪调查。
文章中研究者将这些患者同4605名非癌症个体进行对比研究，相比对照而言，癌症研究组个体每日的活动和机体的活动水平都发生了明显下降，在肺癌患者中改变尤为明显；进行癌症诊断可以增加个体抑郁的风险，但却并不会增加个体患关节炎、失禁及视力/听力问题的风险；同时进行癌症诊断也并不会加剧患者关节炎或足部神经病变的严重性。
研究人员Leach说道，这项前瞻性分析研究利用了一种倾向性的分数将对照组同癌症病例进行对比研究，这就可以帮助我们以一种新的角度来分析癌症和机体老化对健康的效应。相比未患癌的老年个体而言，老年癌症患者中机体功能的下降或许对临床医生而言是一项非常重要线索，因为这种机体功能可以通过方法来改善；临床医生需要改善这些患者机体的功能性水平，同时提供一些干预措施来保护患者的机体功能，从而有效改善老年癌症患者的机体健康。（生物谷Bioon.com）
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Is it my cancer or am i just getting older?: Impact of cancer on age-related health conditions of older cancer survivors
Corinne R. Leach PhD, MS, MPH1,*, Keith M. Bellizzi PhD, MPH2, Arti Hurria MD3 andBryce B. Reeve PhD4
BACKGROUND The extent to which cancer exacerbates or creates new health conditions is a long-standing, unanswered question. The current prospective study examined the short-term impact of cancer on the functioning, development of, and worsening of age-related health conditions among older adults who develop cancer compared with age-matched controls. METHODS Surveillance, Epidemiology, and End Results registry data were linked with Medicare Health Outcomes Survey (MHOS) data. A total of 921 eligible cases were Medicare beneficiaries with diagnosis of breast, colorectal, lung, or prostate cancer made between their baseline and follow-up MHOS. Using propensity score matching, 4605 controls without cancer were matched from the MHOS. Analysis of covariance and logistic regression were used to examine changes in physical functioning, activities of daily living, age-related conditions, and exacerbation of preexisting conditions for cases compared with controls. RESULTS Cancer groups demonstrated greater declines in activities of daily living and physical function compared with controls (mean, -1.53 [standard error, 0.14]), with the greatest change noted for patients with lung cancer (mean, -6.72 [standard error, 0.94]). Having a cancer diagnosis increased the risk of depression but did not increase the odds of developing arthritis in the hand and/or hip, urinary incontinence (except for prostate cancer), or vision and/or hearing problems. Having a cancer diagnosis also did not exacerbate the severity of arthritis or foot neuropathy. CONCLUSIONS The findings of the current study suggest that cancer is a stronger driver for declines in physical functioning and an increased risk of depression in older adults. Interventions are needed to decrease these risks. Clinicians need to prepare patients and families for changes in functioning levels and interventions that limit the declines for older patients with cancer are needed.
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