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微胶囊或可取代针剂胰岛素服务糖尿病患者

  1. 微胶囊
  2. 胰岛素
  3. 针剂

来源:生物谷 2016-05-03 11:21

Insulin microcapsule may replace needle jab Explore further: Novel mechanism of insulin resistance in type 2 diabetesProvided by: Science Network WA  

2016年5月3日讯/生物谷BIOON/--需要注射胰岛素来维持生活方式的西澳大利亚糖尿病患者可能很快就会不用打针了。

这是科廷大学开发的尖端的微胶囊技术,意味着超过10%的西澳大利亚糖尿病患者可以口服胰岛素。很多1型糖尿病患者由于疾病和生活问题必须每天随身携带注射剂和血液监测设备监测身体状况。在不合适的时期和不合适的地方他们注射胰岛素也可能面临尴尬的局面。每日胰岛素注射也引发了患者其它健康问题,如胰岛素抵抗、低血糖(血糖水平低)和高血糖(血糖水平高)。

新的治疗会提供给患者新的希望,因为它会以类似的方式对非糖尿病胰腺输送胰岛素到体内。Hani Al-Salam博士和他的研究团队与uwa合作进行一个项目设计和测试微胶囊对1型糖尿病患者是否是一种可行的替代治疗法。

“这种微胶囊包含胰腺细胞,可植入人体中并传输胰岛素到血液中。”Al-Salami博士说。“自1923年以来,新的治疗方法进入人体试验是针对1型糖尿病首次尝试这种新的胰岛素输送系统。”他说。“在模拟人体长期过程中胶囊试验成功。该胶囊不仅可以促进细胞存活,而且也对细胞的生存和炎症有所改善。”Al-Salami博士说。

长期以来,注射胰岛素促进β细胞进入体内在几十年的实验中一直是失败的,他和他的团队偶然发现,通过添加天然胆汁酸成分的胶囊不仅可以支持细胞在胶囊内生存,还可以减少炎症的发生。(生物谷Bioon.com)

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Insulin microcapsule may replace needle jab

West Australian diabetics who need to inject insulin to maintain their lifestyle may soon be free of the regular needle jab—and the constant annoying questions that go with it.

This is thanks to cutting-edge microcapsule technology developed by Curtin University, which means more than 10 per cent of all of WA's diabetic patients can start taking insulin orally. Many type 1 diabetics live problematic lives due to their illness and having to carry around injection and blood monitoring equipment with them every day.

 Not to mention they may facing a sometimes embarrassing situation of having to inject insulin at inconvenient times and inconvenient places. Daily insulin injections also open the sufferer to other health issues such as insulin resistance, hypoglycemia (low blood sugar level) and hyperglycemia (high blood sugar level). The new treatment could offer new hope to sufferers because it would offer a management regime that delivers insulin to the body in a similar way a non-diabetics pancreas does.

Curtin's Dr Hani Al-Salami and his team, in partnership with UWA, is leading the collaborative project to design and test whether microcapsules are a viable alternative treatment for people with type 1 diabetes. "The microcapsule contains pancreatic cells which can be implanted in the body and deliver insulin to the blood stream," Dr Al-Salami says "If the new treatment gets to human trials it is anticipated to be the first time type 1 diabetes management has tried this new insulin-delivery system, since 1923," he says.

"The capsule has been successfully trialed in a simulated human body for long periods and the capsule has shown not only to be able keep the cells alive, but also support the cells survival and ameliorates inflammation," Dr Al-Salami says. Inserting insulin producing beta cells to the body, long-term, has consistently failed over several decades of trials, he says. "It was by chance that he and his team discovered that by adding naturally occurring bile acid components to the capsule it not only supports cell survival within the capsule, but also reduces inflammation," he says.

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