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AJOG:孕期摄入过多果糖会增加孩子患心脏病的风险

来源:生物谷 2016-04-26 10:49

2016年4月26日讯/生物谷BIOON/--据加尔维斯敦德州大学医疗分部研究人员称,摄入大量的果糖可能会影响几代人的健康。

研究发现,相比只喝水的对照怀孕小鼠,当实验组怀孕小鼠只喝含果糖的甜水,只吃含常见甜味剂的食品和饮料时,那么它们的后代就有更大的患心脏病的风险。这些发现发表在《美国妇产科杂志》上。

这项研究可能对全球人们产生影响,因为大部分的加工食品和碳酸饮料含有高果糖糖浆和甜味剂。最近的研究表明果糖摄入和心血管疾病,肥胖和2型糖尿病等疾病的增长率之间的联系有所上升。

在这项研究中,研究人员调查了怀孕期间高水平的果糖摄入对后代成年人的影像。

在小鼠怀孕期间,研究人员给怀孕的小鼠喂给水或含10%的果糖饮料,模仿大多数软饮料中的果糖水平。而水组和果糖组的饮食是相同的。断奶后,幼崽用水喂给,饮食和正常老鼠的饮食一样,并在一年后进行评估。一岁龄的小鼠被认为是中年老鼠,因为它们的寿命大约是两年。

Antonio Saad和他的研究小组使用计算机断层扫描或CT扫描测量腹部脂肪组织和肝脏脂肪百分比。他们通过血液测试来测量血糖浓度、胰岛素、总胆固醇、甘油三酯和因脂肪细胞产生的leptin-a激素,通过减少饥饿帮助调节能量平衡。

他们发现,果糖组的雌性和雄性后代有更较高的血糖水平和较高的血压水平。与水组小鼠相比,果糖组的雌性后代比较严重,它们的腹部脂肪组织、肝脏脂肪和低浓度的胰岛素抗性水平有较高和较重的比例,并且有较低浓度的瘦蛋白降。无论是哪一组小鼠或者性别,所有的小鼠的总胆固醇或甘油三酯显示无任何差异。

“我们发现,当孕妇在她的饮食中摄入高果糖时,她的后代在成人期会发展成肥胖、高血压和代谢障碍的风险就更高,所有这些都是心血管疾病的危险因素。”Saad说。“这在雌性后代的效果更加显著。在怀孕期间限制摄入高果糖含量食品和饮料可能对孩子的未来健康有很大的影响。”(生物谷Bioon.com)

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High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring

Antonio F. Saad, MD, Joshua Dickerson, Talar B. Kechichian, MS, Huaizhi Yin, Phyllis Gamble, Ashley Salazar, Igor Patrikeev, Massoud Motamedi, PhD, George R. Saade, MD, Maged M. Costantine, MD

Background Consumption of fructose-rich diets in the United States is on the rise and thought to be associated with obesity and cardiometabolic diseases. Objective We sought to determine the effects of antenatal exposure to high-fructose diet on offspring’s development of metabolic syndrome–like phenotype and other cardiovascular disease risk factors later in life. Study Design Pregnant C57BL/6J dams were randomly allocated to fructose solution (10% wt/vol, n = 10) or water (n = 10) as the only drinking fluid from day 1 of pregnancy until delivery. After weaning, pups were started on regular chow, and evaluated at 1 year of life. We measured percent visceral adipose tissue and liver fat infiltrates using computed tomography, and blood pressure using CODA/noninvasive monitor. Intraperitoneal glucose tolerance testing with corresponding insulin concentrations were obtained. Serum concentrations of glucose, insulin, triglycerides, total cholesterol, leptin, and adiponectin were measured in duplicate using standardized assays. Fasting homeostatic model assessment was also calculated to assess insulin resistance. P values <.05 were considered statistically significant. Results Maternal weight, pup number, and average weight at birth were similar between the 2 groups. Male and female fructose group offspring had higher peak glucose and area under the intraperitoneal glucose tolerance testing curve compared with control, and higher mean arterial pressure compared to control. Female fructose group offspring were heavier and had higher percent visceral adipose tissue, liver fat infiltrates, homeostatic model assessment of insulin resistance scores, insulin area under the intraperitoneal glucose tolerance testing curve, and serum concentrations of leptin, and lower concentrations of adiponectin compared to female control offspring. No significant differences in these parameters were noted in male offspring. Serum concentrations of triglycerides or total cholesterol were not different between the 2 groups for either gender. Conclusion Maternal intake of high fructose leads to fetal programming of adult obesity, hypertension, and metabolic dysfunction, all risk factors for cardiovascular disease. This fetal programming is more pronounced in female offspring. Limiting intake of high fructose–enriched diets in pregnancy may have significant impact on long-term health.

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