Science:揭示SPX结构域调节真核细胞内磷酸盐平衡机制
来源:生物谷 2016-04-19 22:55
在一项新的研究中,研究人员报道磷酸盐转运蛋白中的一个被称作SPX结构域的区域指示真菌细胞、植物和人类细胞中的磷酸盐状态。
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Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains
Rebekka Wild1,*, Ruta Gerasimaite2,*, Ji-Yul Jung3,*, Vincent Truffault4, Igor Pavlovic5, Andrea Schmidt2, Adolfo Saiardi6, Henning Jacob Jessen5,7, Yves Poirier3,†, Michael Hothorn1,†, Andreas Mayer
Phosphorus is a macronutrient taken up by cells as inorganic phosphate (Pi). How cells sense cellular Pi levels is poorly characterized. Here we report that SPX domains, which are found in eukaryotic phosphate transporters, signaling proteins and inorganic polyphosphate polymerases, provide a basic binding surface for inositol polyphosphate signaling molecules (InsPs), whose concentrations change in response to Pi availability. Substitutions of critical binding surface residues impair InsP binding in vitro, inorganic polyphosphate synthesis in yeast and Pi transport in Arabidopsis. In plants, InsPs trigger the association of SPX proteins with transcription factors to regulate Pi starvation responses. We propose that InsPs communicate cytosolic Pi levels to SPX domains and enable them to interact with a multitude of proteins to regulate Pi uptake, transport and storage in fungi, plants and animals.
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