新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » 神经科学 » Diabetes Care:睡眠不足或会延长糖尿病患者的认知损伤

Diabetes Care:睡眠不足或会延长糖尿病患者的认知损伤

来源:生物谷 2016-04-12 16:31

图片来源:medicalxpress.com

2016年4月11日 讯 /生物谷BIOON/ --近日,发表于国际杂志Diabetes Care上的一项研究论文中,来自爱丁堡皇家医院(Royal Infirmary of Edinburgh)的研究人员通过研究表示,虽然睡眠不足不会加速因低血糖症而诱导的认知损害,但睡眠不足会延长个体机体发生的认知功能障碍及低血糖症的症状。

文章中,研究人员Berit E. Inkster及其同事对14名1型糖尿病患者进行了研究,这些研究对象为在两个不同场合的高胰岛素血症和低血糖症患者。

研究人员发现,在低血糖症的情况下,认知损伤在睡眠缺失组和睡眠不缺失组的研究对象中的表现并没有显著差异,而在研究对象从睡眠缺失状态中恢复的过程中,参与者的数字符号替换测验分值和选择反应时间表现较差,当睡眠缺失的状态彻底被“移除”后,个体的低血糖症状分值则会明显升高。

研究者认为,糖尿病患者通常会被告知,当缺失睡眠时一旦发生低血糖症就会延长机体认知功能损伤的时间,尽管通过血糖水平的恢复可以帮助缓解认知能力的损伤;而后期研究者表示他们还将进行更为深入的研究来剖析为何睡眠不足会延长个体的认知损伤,从而为后期开发相关疗法来治疗该疾病或将提供新的线索和思路。(生物谷Bioon.com)

本文系生物谷原创编译整理,欢迎转载!点击 获取授权 。更多资讯请下载生物谷APP.

 

Effects of Sleep Deprivation on Hypoglycemia-Induced Cognitive Impairment and Recovery in Adults With Type 1 Diabetes

Berit E. Inkster1⇑, Nicola N. Zammitt1, Stuart J. Ritchie2, Ian J. Deary2, Ian Morrison3 and Brian M. Frier1

 

OBJECTIVE To ascertain whether hypoglycemia in association with sleep deprivation causes greater cognitive dysfunction than hypoglycemia alone and protracts cognitive recovery after normoglycemia is restored. RESEARCH DESIGN AND METHODS Fourteen adults with type 1 diabetes underwent a hyperinsulinemic, hypoglycemic clamp on two separate occasions. Before one glucose clamp, the participants stayed awake overnight to induce sleep deprivation. Participants were randomized and counterbalanced to the experimental condition. Cognitive function tests were performed before and during hypoglycemia and for 90 min after restoration of normoglycemia. RESULTS Cognitive impairment during hypoglycemia did not differ significantly between the sleep-deprived and non–sleep-deprived conditions. However, in the sleep-deprived state, digit symbol substitution scores and choice reaction times were significantly poorer during recovery (P < 0.001) and hypoglycemia symptom scores were significantly higher (P < 0.001), even when symptoms that may have been caused by sleep deprivation, such as tiredness, were removed. CONCLUSIONS Hypoglycemia per se produced a significant decrement in cognitive function; coexisting sleep deprivation did not have an additive effect. However, after restoration of normoglycemia, preceding sleep deprivation was associated with persistence of hypoglycemic symptoms and greater and more prolonged cognitive dysfunction during the recovery period.

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!



相关标签

最新会议 培训班 期刊库