来源：生物谷 2016-04-12 16:31
2016年4月11日 讯 /生物谷BIOON/ --近日，发表于国际杂志Diabetes Care上的一项研究论文中，来自爱丁堡皇家医院（Royal Infirmary of Edinburgh）的研究人员通过研究表示，虽然睡眠不足不会加速因低血糖症而诱导的认知损害，但睡眠不足会延长个体机体发生的认知功能障碍及低血糖症的症状。
文章中，研究人员Berit E. Inkster及其同事对14名1型糖尿病患者进行了研究，这些研究对象为在两个不同场合的高胰岛素血症和低血糖症患者。
Effects of Sleep Deprivation on Hypoglycemia-Induced Cognitive Impairment and Recovery in Adults With Type 1 Diabetes
Berit E. Inkster1⇑, Nicola N. Zammitt1, Stuart J. Ritchie2, Ian J. Deary2, Ian Morrison3 and Brian M. Frier1
OBJECTIVE To ascertain whether hypoglycemia in association with sleep deprivation causes greater cognitive dysfunction than hypoglycemia alone and protracts cognitive recovery after normoglycemia is restored. RESEARCH DESIGN AND METHODS Fourteen adults with type 1 diabetes underwent a hyperinsulinemic, hypoglycemic clamp on two separate occasions. Before one glucose clamp, the participants stayed awake overnight to induce sleep deprivation. Participants were randomized and counterbalanced to the experimental condition. Cognitive function tests were performed before and during hypoglycemia and for 90 min after restoration of normoglycemia. RESULTS Cognitive impairment during hypoglycemia did not differ significantly between the sleep-deprived and non–sleep-deprived conditions. However, in the sleep-deprived state, digit symbol substitution scores and choice reaction times were significantly poorer during recovery (P < 0.001) and hypoglycemia symptom scores were significantly higher (P < 0.001), even when symptoms that may have been caused by sleep deprivation, such as tiredness, were removed. CONCLUSIONS Hypoglycemia per se produced a significant decrement in cognitive function; coexisting sleep deprivation did not have an additive effect. However, after restoration of normoglycemia, preceding sleep deprivation was associated with persistence of hypoglycemic symptoms and greater and more prolonged cognitive dysfunction during the recovery period.