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JN:新研究表明女儿情绪遗传自母亲

来源:生物谷 2016-02-02 11:53

                      

2016年2月2日讯 /生物谷BIOON/ --最近,来自美国加州大学旧金山分校的研究人员对35个家庭进行了研究,结果表明大脑皮层边缘系统的结构模式从母亲遗传到女儿的可能性更大,而从母亲遗传到儿子或从父亲遗传到子女的可能性相对较小。相关研究结果发表在国际学术期刊Journal of Neuroscience上。

一项大型的临床研究曾经表明母亲和女儿在抑郁症的发病上存在很强的关联性,而许多动物研究也表明相比于雄性后代来说,雌性后代更容易应答母亲产前受到的应激并发生情绪相关的脑部结构变化。但是该文章作者表示,在此之前,没有研究能够很好地将这两类研究联系在一起。

皮层边缘系统的重要组成包括海马结构,海马旁回及内嗅区,齿状回,扣带回,乳头体以及杏仁核。该系统主要负责情绪调节和处理,并在抑郁等情绪紊乱疾病的发病过程中发挥一定作用。在这项研究中,研究人员对35个家庭的父母及其子女进行了研究,这些家庭的家庭成员都没有患抑郁症,研究人员利用磁共振成像对皮层边缘系统的灰质体积进行了测量。结果表明母亲与女儿的灰质体积存在非常显著的关联性,并且关联性明显强于母亲与儿子以及父亲与子女的关联性。

这项研究首次使用了MRI技术对父母以及子女脑部结构的代间传递关系进行了研究,为更好地理解抑郁症以及其他精神紊乱疾病的发病机制提供了新信息。(生物谷Bioon.com)

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doi: 10.1523/JNEUROSCI.4974-14.2016 

Female-Specific Intergenerational Transmission Patterns of the Human Corticolimbic Circuitry

Bun Yamagata1,2,3, Kou Murayama4,5, Jessica M. Black6, Roeland Hancock7, Masaru Mimura2, Tony T. Yang7, Allan L. Reiss1, and Fumiko Hoeft

Parents have large genetic and environmental influences on offspring's cognition, behavior, and brain. These intergenerational effects are observed in mood disorders, with particularly robust association in depression between mothers and daughters. No studies have thus far examined the neural bases of these intergenerational effects in humans. Corticolimbic circuitry is known to be highly relevant in a wide range of processes, including mood regulation and depression. These findings suggest that corticolimbic circuitry may also show matrilineal transmission patterns. Therefore, we examined human parent–offspring association in this neurocircuitry and investigated the degree of association in gray matter volume between parent and offspring. We used voxelwise correlation analysis in a total of 35 healthy families, consisting of parents and their biological offspring. We found positive associations of regional gray matter volume in the corticolimbic circuit, including the amygdala, hippocampus, anterior cingulate cortex, and ventromedial prefrontal cortex between biological mothers and daughters. This association was significantly greater than mother–son, father–daughter, and father–son associations. The current study suggests that the corticolimbic circuitry, which has been implicated in mood regulation, shows a matrilineal-specific transmission patterns. Our preliminary findings are consistent with what has been found behaviorally in depression and may have clinical implications for disorders known to have dysfunction in mood regulation such as depression. Studies such as ours will likely bridge animal work examining gene expression in the brains and clinical symptom-based observations and provide promising ways to investigate intergenerational transmission patterns in the human brain.

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