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Plos One:耶鲁研究将生育和加速衰老相联系

来源:生物谷 2016-01-22 10:39

在最近发表于《Plos One》期刊的新研究中,耶鲁大学人类学家揭示了女性生育可能导致加速衰老的首个证据。

研究人员在100位健康绝经后妇女中测试了与加速衰老有关的生物标记物。这些女性来自波兰南部的5个村庄。

这项研究与雅盖隆大学医学院(Jagiellonian University Medical College)和波兰科学院的科学家们合作进行,研究发现:孕次更高的女性--经历更多怀孕、分娩,更多时间哺乳--加速衰老的生物标记物水平高于孕次较低的女性。

经历至少4次怀孕的女性,DNA氧化损伤生物标记物8-OHdG的水平高出20%。身体主要氧化防御酶Cu-Zn SOD水平高出60%,表明氧化应激增加,这是衰老的一个重要促进因素。

这种生育和加速老化之间的生物联系已经在动物被记录,但在人类中从未如此明显。

"和所有生物一样,人们面临繁育和孕妇所在地能量资源有限之间的权衡"该研究共同作者、耶鲁大学人类学教授、生态学和进化生物学教授Richard Bribiescas说,"这项研究首次提供了人类中这种取舍的令人信服的证据。"(生物谷Bioon.com)

DOI: 10.1371/journal.pone.0145753 

Evidence for the Cost of Reproduction in Humans: High Lifetime Reproductive Effort Is Associated with Greater Oxidative Stress in Post-Menopausal Women

Life history theory predicts trade-offs between reproductive effort and maternal survivorship in energy-restricted environments. However, empirical evidence for the positive association between maternal mortality and reproductive effort from energetically challenged human populations are mixed and physiological mechanisms that may underlie this association are poorly understood. We hypothesized that increases in aerobic metabolism during repeated periods of pregnancy and lactation result in increased oxidative stress that may contribute to somatic deterioration, vulnerability to illness, and accelerated aging. We therefore predicted that lifetime gravidity and parity would be related to levels of biomarkers of oxidative stress, as well as antioxidative defence enzymes in post-menopausal women. Our hypothesis was supported by positive linear associations between levels of 8-OHdG, a biomarker of DNA oxidative damage (β = 0.21, p<0.05), levels of antioxidative defence enzyme Cu-Zn SOD (β = 0.25, p<0.05), and number of lifetime pregnancies. Furthermore, independent of age and health status, post-menopausal women with higher gravidity and parity (> = 4 pregnancies per lifetime) had 20% higher levels of 8-OHdG and 60% higher levels of Cu-Zn SOD compared to women with lower gravidity and parity (<4 pregnancies per lifetime). Our results present the first evidence for oxidative stress as a possible cost of reproductive effort in humans.

 

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