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首页 » 癌症研究 » JAMA Dermatol:β-人类乳头瘤病毒或可致人患皮肤癌

JAMA Dermatol:β-人类乳头瘤病毒或可致人患皮肤癌

来源:生物谷 2016-01-07 15:35

图片来源:medicalxpress.com

2016年1月7日 讯 /生物谷BIOON/ --近日,刊登在国际杂志JAMA Dermatology上的一篇研究论文中,来自德克萨斯大学健康科学中心的科学家通过研究发现,β-人类乳头瘤病毒(β-HPV)或许是健康人患皮肤鳞状细胞癌(cSCC)的风险因子。

文章中,研究者Jad Chahoud跟同事对此前进行的人类相关的研究进行了一项系统性的文献回顾,其中包括对免疫活性个体的研究,目的在于计算总体的皮肤鳞状细胞患者同β-人类乳头瘤病毒引发的皮肤鳞状细胞患者之间的优势比。

基于对此前的14项研究进行分析汇总(包括3112名cSCC患者及6020名对照个体),研究人员发现,β-HPV和cSCC之间的总体相关性比较明显(调整的优势比,1.42),在特异性关联分析中5, 8, 15, 17, 20, 24, 36和38型β-人类乳头瘤病毒和个体患皮肤鳞状细胞癌之间具有明显的关联;而仅在利用血清学进行HPV检测的研究中,对病毒亚型进行分析表明,总体的β-HPV和HPV亚型5, 8, 17, 20, 24及38,同个体患皮肤鳞状细胞癌风险增加直接相关。

最后研究者在文章中写道,对病毒亚型进行分析发现HPV 5, 8, 17, 20和38型同个体患癌之间存在明显关联,这或许可以帮助指导未来HPV病毒的干预措施;研究人员希望通过后期研究可以帮助开发有效抵御病毒感染及个体患癌的思路。(生物谷Bioon.com)

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Association Between β-Genus Human Papillomavirus and Cutaneous Squamous Cell Carcinoma in Immunocompetent Individuals—A Meta-analysis

Jad Chahoud, MD1; Adele Semaan, MPH2; Yong Chen, PhD3; Ming Cao, BS3; Alyssa G. Rieber, MD4; Peter Rady, MD, PhD5; Stephen K. Tyring, MD, PhD, MBA5

Importance Existing epidemiological evidence remains controversial regarding the association between β-genus human papillomavirus (β-HPV) and cutaneous squamous cell carcinoma (cSCC) in immunocompetent individuals. Objective We aimed to clarify this association and evaluate type-specific β-HPV involvement. Data Sources We performed a systematic literature search of MEDLINE and EMBASE for studies in humans through June 18, 2014, with no restriction on publication date or language. The following search terms were used: “human papillomavirus” and “cutaneous squamous cell carcinoma or skin squamous cell carcinoma or cSCC or nonmelanoma skin neoplasms.” Study Selection Articles were independently assessed by 2 reviewers. We only included case-control or cohort studies, in immunocompetent individuals, that calculated the odds ratio (OR) for cSCC associated with overall and type-specific β-HPV. Data Extraction and Synthesis We first assessed the heterogeneity among study-specific ORs using the Q statistic and I2 statistic. Then, we used the random-effects model to obtain the overall OR and its 95% CI for all studies as well as for each type of HPV. We also tested and corrected for publication bias by 3 funnel plot–based methods. The quality of each study was assessed with The Newcastle Ottowa scale. Main Outcomes and Measures Pooled ORs and 95% CIs for overall β-HPV and HPV types 5, 8, 15, 17, 20, 24, 36, and 38 association with skin biopsy proven cSCC. Results Seventy-nine articles were assessed for elligibility; 14 studies met inclusion criteria for the meta-analysis and included 3112 adult immunocompetent study participants with cSCC and 6020 controls. For all detection methods, the overall association between β-HPV and cSCC was significant with an adjusted pooled OR (95% CI) of 1.42 (1.18-1.72). As for the type-specific analysis, types 5, 8, 15, 17, 20, 24, 36, and 38 showed a significant association with adjusted pooled ORs (95% CIs) of 1.4 (1.18-1.66), 1.39 (1.16-1.66), 1.25 (1.04-1.50), 1.34 (1.19-1.52), 1.38(1.21-1.59), 1.26 (1.09-1.44), 1.23 (1.01-1.50) and 1.37 (1.13-1.67) respectively. Our subgroup analysis in studies using only serology for HPV detection showed a significant association between overall β-HPV and HPV subtypes 5, 8, 17, 20, 24, and 38 with an increased risk of cSCC development. Conclusions and Relevance This study serves as added evidence supporting β-HPV as a risk factor for cSCC in healthy individuals. The subgroup analysis highlights this significant association for HPV 5, 8, 17, 20, and 38, which may help to direct future prevention efforts.

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