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EbioMedicine:打破HIV多年治疗误区!疗法虽成功但病毒水平丝毫未减

来源:生物谷 2015-08-05 10:00

2015年8月5日 讯 /生物谷BIOON/ --发表于国际杂志EbioMedicine上的一篇研究报道中,来自利物浦大学的科学家通过研究发现,尽管HIV患者对疗法反应较好,但HIV仍然可以在患者机体中旺盛地生长。

在疗法期间,HIV会在免疫细胞中隐藏,病毒往往会通过将其自身的遗传信息插入到免疫细胞CD4 T淋巴细胞的DNA中来在细胞中繁殖。文章中研究者对进行长达14年连续疗法的HIV患者进行研究,测定了患者机体中CD4细胞中含有的整合HIV的水平,同时对比了治疗不同时间段的患者机体HIV的水平变化。

结果研究者发现,丛治疗1年至14年里,整合入CD4淋巴细胞的HIV的水平并未减弱,每当CD4细胞复制产生更多细胞时,HIV就会进行自身的增殖,该过程被认为是HIV的静默复制过程,意味着病毒并不需要进行自我复制,而是产生更多新型的病毒颗粒从而感染更多的CD4淋巴细胞。

给HIV患者施用抗逆转录病毒的疗法会阻断新病毒的产生,并且抑制CD4 T淋巴细胞的感染和死亡以及AIDS的进展。过去30年的HIV抗逆转录病毒疗法对于很多患者而言的确将患者机体的病毒控制在了一定的水平之下,并且可以维持患者长久健康的生活,而且研究者也认为在进行了许多年的成功治疗后,患者的机体就会有效清除病毒。

研究者Anna Maria Geretti教授说道,本文研究则表明,HIV或许一直在以其它方式来逃脱疗法的攻击;我们一直认为HIV非常难以完全抑制,而且HIV会在CD4细胞中隐蔽自己,但我们还是希望随着机体不断更新CD4细胞,隐藏的HIV就会慢慢被干掉,然而让我们震惊的是,整合入CD4细胞中的HIV的水平在患者成功治疗的14年间并没有发生任何降低。

好消息是在患者治疗期间研究者并没有看到患者疾病恶化的表现,但坏消息是,我们一直认为通过增加机体免疫反应来有效治疗HIV感染似乎并不太奏效,因为HIV在患者机体中的水平似乎一直没有发生变化。(生物谷Bioon.com)

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HIV grows despite treatment, study finds

HIV can continue to grow in patients who are thought to be responding well to treatment, according to research by the University of Liverpool.

During treatment for HIV the virus hides in blood cells that are responsible for the patient's immune response. The virus does this by inserting its own genetic information into the DNA of the blood cells, called CD4 Tlymphocytes.

The study by the University's Institute of Infection and Global Health measured the levels of integrated HIV in the CD4 cells of patients undergoing uninterrupted treatment for up to 14 years, and compared patients receiving treatment for different lengths of time.

The researchers discovered that the amount of HIV found to be integrated in the CD4 cells was undiminished from year 1 to year 14.

The research demonstrates that whenever a CD4 cell multiplies to produce more cells, it copies itself and also copies the HIV genes. This process - a sort of silent HIV replication - means the virus does not need to copy itself, produce new virus particles, and infect new CD4 cells - but is automatically incorporated at the birth of the cell.

Anti-retroviral therapy is given to HIV patients to stop the production of new virus which prevents the infection and death of CD4 T-lymphocytes and the progression of the disease to full-blown AIDS.

Advances in anti-retroviral therapy over the last 30 years mean that most patients can have their virus suppressed to almost undetectable levels and live a long and healthy life. It had been thought that after many years of successful treatment, the body would naturally purge itself of the virus.

Professor Anna Maria Geretti, who led the study, said: "This research shows that sadly, the HIV virus has found yet another way to escape our treatments.

"We always knew HIV is difficult to suppress completely and that it hides inside CD4 cells, but we always hoped that as the body gradually renews its CD4 cells that the hidden HIV would die out. We were surprised to find that the levels of HIV integrated in the CD4 cells didn't reduce over the 14-year period.

"The good news is that we did not see any worsening over time, but the bad news is that these findings really cast doubt over whether HIV can be 'cured' by increasing immune cell responses against it - a strategy that now looks like it will eventually fail."

The results are published in the journal 'EBioMedicine'.

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