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姜黄素或可有效抵御恶性间皮瘤的发展

来源:生物谷 2015-07-06 15:00

2015年7月6日 讯 /生物谷BIOON/ --千百年来美食爱好者一直钟情于食物丰富的颜色、辛辣的味道以及阵阵香气,而如今研究者发现姜黄根或可帮助抵御癌症;近日来自弗林德斯大学的研究人员通过研究调查了是否将黄根的有效成分姜黄素可以独立或结合标准疗法来帮助治疗恶性间皮瘤,这是一种因吸入石棉而引发的恶性癌症。

恶性间皮瘤是一种围绕在肺部、心脏及腹部内部器官表面的薄膜性肿瘤,当前并没有有效疗法来治疗这种癌症。研究者Sonja Klebe教授说道,标准的化疗方法成功率有限,而根治性的手术也仅适用于很少一部分患者,而且并不能保证每次都成功。恶性间皮瘤患者诊断后的平均生存时间不到一年,当前治疗该患者的疗法往往使患者非常痛苦。

长期以来姜黄素被认为具有明显的抗炎效应,而且近来研究者发现姜黄素具有抗癌特性,其可以帮助克服癌细胞对化疗的耐药性;此前在实验室中研究者利用姜黄素成功抑制了动物模型细胞中间皮瘤的生长,而如今研究者利用姜黄素可以成功抑制人类机体中间皮瘤的发展,这或许就可以帮助预测是否患者会得益于这种新型的姜黄素疗法。

另外研究者还发现姜黄素会影响肿瘤的血液供给,从传统意义上来讲,新生血管被认为可以从围绕在肿瘤周围存在的间质血管中发芽生成,而血管内皮生长因子则可以促进该过程的发生,同时间皮细胞还可以展现血管内皮生长因子受体,截至目前为止,靶向作用血管内皮生长因子的药物依然没有取得治疗上的成功。

研究者Klebe说道,本文中我们首次发现间皮瘤细胞自身可以形成3维的导管,这或可帮助解释标准药物治疗效果较差的原因,即标准药物并不能靶向作用不同类型肿瘤血管的生成;研究者认为,姜黄素在间皮瘤中血管发生中扮演着重要角色,尤其是姜黄素对于肿瘤的生长具有直接的效应。

姜黄素通常以口服药片的形式呈现,实际上其并没有任何副作用,还可以单独用于治疗患者,来帮助患者机体有效抵御癌细胞耐药性的产生,当然姜黄素还可以结合其它疗法来帮助改善机体对疗法的反应,并且降低标准化药物的用量,从而最终改善患者的生活质量。(生物谷Bioon.com)

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Spicy treatment the answer to aggressive cancer?

It has been treasured by food lovers for thousands of years for its rich golden colour, peppery flavour and mustardy aroma…and now turmeric may also have a role in fighting cancer.

Researchers at Flinders are investigating whether an active ingredient of the turmeric plant, called curcumin, can be used alone or in conjunction with standard therapies to treat malignant mesothelioma, an aggressive cancer caused by the inhalation of asbestos.

Malignant mesothelioma is a tumour of the thin membranes that surround the lungs, heart and abdominal internal organs. Currently there is no effective treatment for the cancer.

"Standard chemotherapy shows only limited success, and radical surgery is only available to few patients, and success is not guaranteed," explained lead researcher Associate Professor Sonja Klebe, from the Department of Anatomical Pathology at Flinders Medical Centre.

Associate Professor Klebe said average survival after diagnosis of malignant mesothelioma was less than a year, and current therapies to treat the cancer could make patients quite unwell.

Curcumin has long been known to have anti-inflammatory effects and more recently, has been shown to have anti-carcinogenic properties which help overcome drug resistance to chemotherapy.

"Previous research has been successful in inhibiting the growth of mesothelioma tumour cells in animal model cells in a laboratory setting using curcumin, and recently we have been able to repeat that success – but with the use of patients' cells," said Professor Klebe.....

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