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PLoS ONE:电刺激疗法或可加速伤口的愈合

  1. 伤口
  2. 愈合
  3. 电刺激疗法
  4. 血管

来源:生物谷 2015-05-15 11:40

近日,发表于国际杂志PLoS ONE上的一篇研究论文中,来自曼切斯特大学的研究人员通过对40位志愿者进行研究揭示了电刺激如何加速伤口的愈合;皮肤伤口愈合较慢一直是全球科学家们研究的一大挑战,每年英国国家医疗服务系统都会花费10亿英镑来治疗那些患慢性创伤的患者,比如下肢或糖尿病溃疡等,一旦伤口无法愈合就会变成慢性疾病。

2015年5月15日 讯 /生物谷BIOON/ --近日,发表于国际杂志PLoS ONE上的一篇研究论文中,来自曼切斯特大学的研究人员通过对40位志愿者进行研究揭示了电刺激如何加速伤口的愈合;皮肤伤口愈合较慢一直是全球科学家们研究的一大挑战,每年英国国家医疗服务系统都会花费10亿英镑来治疗那些患慢性创伤的患者,比如下肢或糖尿病溃疡等,一旦伤口无法愈合就会变成慢性疾病。

如今研究人员对40名志愿者进行伤口愈合的研究,相关研究或为开发新型设备或疗法来加速治疗伤口愈合提供帮助。研究中研究人员首先在每个志愿者的上臂位置制造产生半厘米大的无害伤口,其中一处位于左侧的伤口让其进行自然痊愈,而另外一侧伤口则利用电刺激进行为期2周的治疗,这些电脉冲会通过刺激产生新的血管来加速伤口愈合。

结果显示,电刺激在伤口愈合上非常有效,因此研究者就认为这种技术或许可以应用于任何情况来帮助患者机体加速伤口的愈合,比如外科伤口、军事创伤或者运动创伤等。

研究者Ardeshir Bayat说道,伤口愈合,尤其是慢性伤口的治疗一直以来都是全球性的研究焦点,如今这种电刺激技术或为治疗慢性创伤愈合提供一定的希望;当其用于急性或慢性伤口时就可以加速伤口的功能性愈合,从而为改善患者的生活质量及病情带来巨大帮助。(生物谷Bioon.com)

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Angiogenesis Is Induced and Wound Size Is Reduced by Electrical Stimulation in an Acute Wound Healing Model in Human Skin

Sara Ud-Din, Anil Sebastian, Pamela Giddings, James Colthurst, Sigrid Whiteside, Julie Morris, Richard Nuccitelli, Christine Pullar, Mo Baguneid, Ardeshir Bayat

Angiogenesis is critical for wound healing. Insufficient angiogenesis can result in impaired wound healing and chronic wound formation. Electrical stimulation (ES) has been shown to enhance angiogenesis. We previously showed that ES enhanced angiogenesis in acute wounds at one time point (day 14). The aim of this study was to further evaluate the role of ES in affecting angiogenesis during the acute phase of cutaneous wound healing over multiple time points. We compared the angiogenic response to wounding in 40 healthy volunteers (divided into two groups and randomised), treated with ES (post-ES) and compared them to secondary intention wound healing (control). Biopsy time points monitored were days 0, 3, 7, 10, 14. Objective non-invasive measures and H&E analysis were performed in addition to immunohistochemistry (IHC) and Western blotting (WB). Wound volume was significantly reduced on D7, 10 and 14 post-ES (p = 0.003, p = 0.002, p<0.001 respectively), surface area was reduced on days 10 (p = 0.001) and 14 (p<0.001) and wound diameter reduced on days 10 (p = 0.009) and 14 (p = 0.002). Blood flow increased significantly post-ES on D10 (p = 0.002) and 14 (p = 0.001). Angiogenic markers were up-regulated following ES application; protein analysis by IHC showed an increase (p<0.05) in VEGF-A expression by ES treatment on days 7, 10 and 14 (39%, 27% and 35% respectively) and PLGF expression on days 3 and 7 (40% on both days), compared to normal healing. Similarly, WB demonstrated an increase (p<0.05) in PLGF on days 7 and 14 (51% and 35% respectively). WB studies showed a significant increase of 30% (p>0.05) on day 14 in VEGF-A expression post-ES compared to controls. Furthermore, organisation of granulation tissue was improved on day 14 post-ES. This randomised controlled trial has shown that ES enhanced wound healing by reduced wound dimensions and increased VEGF-A and PLGF expression in acute cutaneous wounds, which further substantiates the role of ES in up-regulating angiogenesis as observed over multiple time points. This therapeutic approach may have potential application for clinical management of delayed and chronic wounds.

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