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ACS Applied Materials & Interfaces:石墨烯---还能治蛀牙

来源:生物谷 2015-03-13 10:28

2015年3月13日 讯 /生物谷BIOON/ --牙科疾病是由于某些口腔细菌的生长而引起的,这是世界上最常见的健康问题。科学家们发现一种石墨烯氧化物材料可有效地消除这些细菌,这些细菌中的其中一些已经产生了抗生素耐药性。这一发现发表在《ACS Applied Materials & Interfaces》。

Zisheng Tang和他的同事们通过研究发现,牙医经常给病人开一些传统抗生素以去除引起蛀牙和牙龈疾病的细菌。但是随着抗生素耐药性的增加,需要新的方法来解决这些问题,因为使用这些方法终会导致牙齿脱落。先前的研究已经表明,氧化石墨烯,石墨烯片存在于氧分子团中,这在生物医学应用中是一种很有前途的材料。它可以抑制一些菌株的生长,但对哺乳动物细胞只有轻微伤害。Tang研究组想了解纳米片是否会抑制口腔疾病中特定细菌的生长。

在实验室中,研究人员测试了该材料对导致蛀牙和牙龈疾病的三个不同种类细菌的作用。通过破坏细菌细胞壁和细胞膜,石墨烯氧化物有效的抑制了病原菌的生长。研究人员因此得出结论,石墨烯片可能在牙科保健上有潜在的使用价值。

该项研究由上海自然科学基金和上海交通大学“医工(理)交叉研究”提供资金支持。

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Killing Dental Pathogens Using Antibacterial Graphene Oxide

Jianliang He, Xiaodan Zhu, Zhengnan Qi, Chang Wang, Xiaojun Mao, Cailian Zhu, Zhiyan He, Mingyu Li, Zisheng Tang.

Dental diseases, which are caused by the overgrowth of certain bacteria in the mouth, are among the most common health problems in the world. Now scientists have discovered that a material called graphene oxide is effective at eliminating these bacteria, some of which have developed antibiotic resistance. They report the findings in the journal ACS Applied Materials & Interfaces. Zisheng Tang and colleagues point out that dentists often prescribe traditional antibiotics to get rid of bacteria that cause tooth decay or gum disease. But with the rise in antibiotic resistance, new approaches are needed to address these problems, which can lead to tooth loss. Previous studies have demonstrated that graphene oxide -- carbon nanosheets studded with oxygen groups -- is a promising material in biomedical applications. It can inhibit the growth of some bacterial strains with minimal harm to mammalian cells. Tang's team wanted to see if the nanosheets would also stop the specific bacteria that cause dental diseases.

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